'Late' chorionic villus sampling: Cytogenetic aspects

L. Dalpra, G. Nocera, M. G. Tibiletti, E. Martinoli, A. Oldrini, S. Agosti, P. G. Crosignani

Research output: Contribution to journalArticle

Abstract

Cytogenetic data about 145 chorionic villus samples obtained between the 13th and 35th week of gestation are reported. 'Late' chorionic villus sampling (CVS) was used to resolve different situations: failed amniotic fluid cell cultures (5 cases); confirmation of an abnormal karyotype, previously diagnosed as mosaic (14 cases); and ultrasound fetal malformation (23 cases). Most of the samples (103 cases) were analysed for the classical indications and in these cases, the principal aim was to obtain a rapid fetal karyotype. Excluding the cases used to check fetal karyotype, a chromosomal aberration was found in 11 out of 131 biopsies. In four cases of the group in which the fetal karyotype was checked (14 cases), the pathology observed at the first diagnosis was confirmed, while in the remaining ten cases the anomaly was not observed.

Original languageEnglish
Pages (from-to)239-246
Number of pages8
JournalPrenatal Diagnosis
Volume13
Issue number4
Publication statusPublished - 1993

Keywords

  • Cytogenetic abnormality
  • Prenatal diagnosis
  • Transabdominal late CVS

ASJC Scopus subject areas

  • Genetics(clinical)
  • Obstetrics and Gynaecology

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    Dalpra, L., Nocera, G., Tibiletti, M. G., Martinoli, E., Oldrini, A., Agosti, S., & Crosignani, P. G. (1993). 'Late' chorionic villus sampling: Cytogenetic aspects. Prenatal Diagnosis, 13(4), 239-246.