Late complications after hematopoietic stem cell transplantation

André Tichelli, Alicia Rovó, Jakob Passweg, Carl Philipp Schwarze, Maria Teresa Van Lint, Mutlu Arat, Gérard Socié

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Hematopoietic stem cell transplantation (HSCT) offers the opportunity for cure to patients with leukemia, lymphoma and severe non-malignant diseases. More than 40,000 HSCTs are performed annually worldwide. Therefore, the number of long-term survivors, free of the disease for which they were transplanted is continuously increasing. Despite the improved prognosis of HSCT, long-term outcome may be impaired by transplant-associated morbidity and mortality. Long-term survivors can present a variety of malignant and non-malignant complications, impairing physical and psychological performance, normal integration in family and social life, and quality of life. Conditioning regimens, particularly when including total-body irradiation as well as graft-versus-host disease, play a key role in the development of late effects. However, with increasing time since transplantation new types of late effects may emerge. Awareness on long-term effects after HSCT is crucial to provide adapted pretransplant counseling, and recommendations for post-transplant screening, prevention and early treatment.

Original languageEnglish
Pages (from-to)583-601
Number of pages19
JournalExpert Review of Hematology
Volume2
Issue number5
DOIs
Publication statusPublished - 2009

Fingerprint

Hematopoietic Stem Cell Transplantation
Survivors
Quality of Life
Transplants
Whole-Body Irradiation
Graft vs Host Disease
Counseling
Lymphoma
Leukemia
Transplantation
Psychology
Morbidity
Mortality
Therapeutics

Keywords

  • Hematopoietic stem cell transplantation
  • Late effects
  • Long-term quality of life
  • Malignant complications
  • Non-malignant complications
  • Performance
  • Survivorship

ASJC Scopus subject areas

  • Hematology

Cite this

Tichelli, A., Rovó, A., Passweg, J., Schwarze, C. P., Van Lint, M. T., Arat, M., & Socié, G. (2009). Late complications after hematopoietic stem cell transplantation. Expert Review of Hematology, 2(5), 583-601. https://doi.org/10.1586/ehm.09.48

Late complications after hematopoietic stem cell transplantation. / Tichelli, André; Rovó, Alicia; Passweg, Jakob; Schwarze, Carl Philipp; Van Lint, Maria Teresa; Arat, Mutlu; Socié, Gérard.

In: Expert Review of Hematology, Vol. 2, No. 5, 2009, p. 583-601.

Research output: Contribution to journalArticle

Tichelli, A, Rovó, A, Passweg, J, Schwarze, CP, Van Lint, MT, Arat, M & Socié, G 2009, 'Late complications after hematopoietic stem cell transplantation', Expert Review of Hematology, vol. 2, no. 5, pp. 583-601. https://doi.org/10.1586/ehm.09.48
Tichelli, André ; Rovó, Alicia ; Passweg, Jakob ; Schwarze, Carl Philipp ; Van Lint, Maria Teresa ; Arat, Mutlu ; Socié, Gérard. / Late complications after hematopoietic stem cell transplantation. In: Expert Review of Hematology. 2009 ; Vol. 2, No. 5. pp. 583-601.
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