Late complications after hematopoietic stem cell transplantation

André Tichelli, Alicia Rovó, Jakob Passweg, Carl Philipp Schwarze, Maria Teresa Van Lint, Mutlu Arat, Gérard Socié

Research output: Contribution to journalArticle


Hematopoietic stem cell transplantation (HSCT) offers the opportunity for cure to patients with leukemia, lymphoma and severe non-malignant diseases. More than 40,000 HSCTs are performed annually worldwide. Therefore, the number of long-term survivors, free of the disease for which they were transplanted is continuously increasing. Despite the improved prognosis of HSCT, long-term outcome may be impaired by transplant-associated morbidity and mortality. Long-term survivors can present a variety of malignant and non-malignant complications, impairing physical and psychological performance, normal integration in family and social life, and quality of life. Conditioning regimens, particularly when including total-body irradiation as well as graft-versus-host disease, play a key role in the development of late effects. However, with increasing time since transplantation new types of late effects may emerge. Awareness on long-term effects after HSCT is crucial to provide adapted pretransplant counseling, and recommendations for post-transplant screening, prevention and early treatment.

Original languageEnglish
Pages (from-to)583-601
Number of pages19
JournalExpert Review of Hematology
Issue number5
Publication statusPublished - 2009


  • Hematopoietic stem cell transplantation
  • Late effects
  • Long-term quality of life
  • Malignant complications
  • Non-malignant complications
  • Performance
  • Survivorship

ASJC Scopus subject areas

  • Hematology

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  • Cite this

    Tichelli, A., Rovó, A., Passweg, J., Schwarze, C. P., Van Lint, M. T., Arat, M., & Socié, G. (2009). Late complications after hematopoietic stem cell transplantation. Expert Review of Hematology, 2(5), 583-601.