Late deaths and second primary malignancies among long-term survivors of childhood cancer: An Italian multicentre study

Benedetto Terracini, Guido Pastore, Maria Grazia Zurlo, Giuseppe Masera, Franca Fossati-Bellani, Manuel Castello, Paolo Tamaro, Fausta Massolo, Domenico Rosati, Pier Franco Biddau, Antonio Russo

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Abstract

A multicentre registry of children who had been successfully removed from therapy for some common childhood cancers (Hodgkin's disease, non-Hodgkin's lymphoma, neuroblastoma, nephroblastoma, acute lymphatic leukaemia and other leukaemias) was established in Italy in 1981. The present study describes mortality and occurrence of second primary malignancies (SPMs) among 1467 children who were alive when the registry was established. Follow-up ended on December 31, 1983 for mortality and 1 year later for the occurrence of SPMs. Sixty-seven deaths were recorded, 11 of which wre due to causes other than progression of the original disease. Eleven incident SPMs were identified (i.e. 3 acute myeloid leukaemias, 3 thyroid carcinomas, 1 bilateral breast carcinoma, 1 liver malignant mesenchymoma, 1 astrocytoma, 1 chondrosarcoma and 1 osteosarcoma) corresponding to an incidence rate of 2.1 1000 patient-years at risk. Anecdotal reports were collected regarding 2 further SPMs (a thyroid carcinoma and a myeloid leukaemia) as well as several benign tumours, including 2 mammary fibroadenomas.

Original languageEnglish
Pages (from-to)499-504
Number of pages6
JournalEuropean Journal of Cancer and Clinical Oncology
Volume23
Issue number5
DOIs
Publication statusPublished - 1987

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Second Primary Neoplasms
Multicenter Studies
Survivors
Thyroid Neoplasms
Registries
Neoplasms
Leukemia
Fibroadenoma
Chondrosarcoma
Myeloid Leukemia
Wilms Tumor
Mortality
Astrocytoma
Osteosarcoma
Hodgkin Disease
Neuroblastoma
Acute Myeloid Leukemia
Non-Hodgkin's Lymphoma
Italy
Disease Progression

ASJC Scopus subject areas

  • Oncology

Cite this

Late deaths and second primary malignancies among long-term survivors of childhood cancer : An Italian multicentre study. / Terracini, Benedetto; Pastore, Guido; Grazia Zurlo, Maria; Masera, Giuseppe; Fossati-Bellani, Franca; Castello, Manuel; Tamaro, Paolo; Massolo, Fausta; Rosati, Domenico; Franco Biddau, Pier; Russo, Antonio.

In: European Journal of Cancer and Clinical Oncology, Vol. 23, No. 5, 1987, p. 499-504.

Research output: Contribution to journalArticle

Terracini, B, Pastore, G, Grazia Zurlo, M, Masera, G, Fossati-Bellani, F, Castello, M, Tamaro, P, Massolo, F, Rosati, D, Franco Biddau, P & Russo, A 1987, 'Late deaths and second primary malignancies among long-term survivors of childhood cancer: An Italian multicentre study', European Journal of Cancer and Clinical Oncology, vol. 23, no. 5, pp. 499-504. https://doi.org/10.1016/0277-5379(87)90309-9
Terracini, Benedetto ; Pastore, Guido ; Grazia Zurlo, Maria ; Masera, Giuseppe ; Fossati-Bellani, Franca ; Castello, Manuel ; Tamaro, Paolo ; Massolo, Fausta ; Rosati, Domenico ; Franco Biddau, Pier ; Russo, Antonio. / Late deaths and second primary malignancies among long-term survivors of childhood cancer : An Italian multicentre study. In: European Journal of Cancer and Clinical Oncology. 1987 ; Vol. 23, No. 5. pp. 499-504.
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