Late gadolinium enhancement by cardiovascular magnetic resonance is complementary to left ventricle ejection fraction in predicting prognosis of patients with stable coronary artery disease

Oronzo Catalano, Guido Moro, Mariarosa Perotti, Mauro Frascaroli, Monica Ceresa, Serena Antonaci, Paola Baiardi, Carlo Napolitano, Maurizia Baldi, Silvia G. Priori

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Abstract

Background: Late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) predicts adverse prognosis in patients with stable coronary artery disease (CAD). However, the interaction with conventional risk factors remains uncertain. Our aim was to assess whether the extent of LGE is an independent predictor of adverse cardiac outcome beyond conventional risk factors, including left ventricle ejection fraction (LVEF). Methods: We enrolled 376 patients (88% males, 64 11 years) with stable CAD, who underwent LGE assessment and a detailed conventional evaluation (clinical and pharmacological history, risk factors, ECG, Echocardiography). During a follow-up of 38 21 months, 56 events occurred (32 deaths, 24 hospitalizations for heart failure). Results: LGE and LVEF showed the strongest univariate associations with end-points (HR: 13.61 [95%C.I.: 7.32-25.31] for LGE ≥ 45% of LV mass; and 12.34 [6.80-22.38] for LVEF ≤ 30%; p

Original languageEnglish
Article number29
JournalJournal of Cardiovascular Magnetic Resonance
Volume14
Issue number1
DOIs
Publication statusPublished - 2012

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Family Practice
  • Medicine(all)

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