TY - JOUR
T1 - Late gadolinium enhancement by cardiovascular magnetic resonance is complementary to left ventricle ejection fraction in predicting prognosis of patients with stable coronary artery disease
AU - Catalano, Oronzo
AU - Moro, Guido
AU - Perotti, Mariarosa
AU - Frascaroli, Mauro
AU - Ceresa, Monica
AU - Antonaci, Serena
AU - Baiardi, Paola
AU - Napolitano, Carlo
AU - Baldi, Maurizia
AU - Priori, Silvia G.
PY - 2012
Y1 - 2012
N2 - Background: Late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) predicts adverse prognosis in patients with stable coronary artery disease (CAD). However, the interaction with conventional risk factors remains uncertain. Our aim was to assess whether the extent of LGE is an independent predictor of adverse cardiac outcome beyond conventional risk factors, including left ventricle ejection fraction (LVEF). Methods: We enrolled 376 patients (88% males, 64 11 years) with stable CAD, who underwent LGE assessment and a detailed conventional evaluation (clinical and pharmacological history, risk factors, ECG, Echocardiography). During a follow-up of 38 21 months, 56 events occurred (32 deaths, 24 hospitalizations for heart failure). Results: LGE and LVEF showed the strongest univariate associations with end-points (HR: 13.61 [95%C.I.: 7.32-25.31] for LGE ≥ 45% of LV mass; and 12.34 [6.80-22.38] for LVEF ≤ 30%; p
AB - Background: Late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) predicts adverse prognosis in patients with stable coronary artery disease (CAD). However, the interaction with conventional risk factors remains uncertain. Our aim was to assess whether the extent of LGE is an independent predictor of adverse cardiac outcome beyond conventional risk factors, including left ventricle ejection fraction (LVEF). Methods: We enrolled 376 patients (88% males, 64 11 years) with stable CAD, who underwent LGE assessment and a detailed conventional evaluation (clinical and pharmacological history, risk factors, ECG, Echocardiography). During a follow-up of 38 21 months, 56 events occurred (32 deaths, 24 hospitalizations for heart failure). Results: LGE and LVEF showed the strongest univariate associations with end-points (HR: 13.61 [95%C.I.: 7.32-25.31] for LGE ≥ 45% of LV mass; and 12.34 [6.80-22.38] for LVEF ≤ 30%; p
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U2 - 10.1186/1532-429X-14-29
DO - 10.1186/1532-429X-14-29
M3 - Article
C2 - 22607320
AN - SCOPUS:84863227579
VL - 14
JO - Journal of Cardiovascular Magnetic Resonance
JF - Journal of Cardiovascular Magnetic Resonance
SN - 1097-6647
IS - 1
M1 - 29
ER -