Abstract
Background/Aim: The aim of the study was to evaluate the prognostic power of late-life depression (LLD) compared with amnestic mild cognitive impairment (aMCI) for the onset of Alzheimer's disease (AD) within 4 years of follow-up. Methods: We estimated the incidence of AD in 60 patients presenting with aMCI, 115 patients suffering of LLD treated with antidepressants with good compliance, and 66 healthy control (HC) patients, followed for 4 years. Results: The risk to develop AD, within 4 years, was 68.33% for aMCI and 49.57% for LLD. In AD patients 5.60% deteriorated without depression, and 72.20% deteriorated with depression after 4 years of follow-up (p < 0.0001). No HC patients deteriorated to AD or any other dementia type. Conclusion: In our results, aMCI was the first predictive condition that increased the risk to develop AD. Depression is a potentially preventable medical condition across the lifespan and may be a modifiable risk factor.
| Original language | English |
|---|---|
| Pages (from-to) | 140-153 |
| Number of pages | 14 |
| Journal | Dementia and Geriatric Cognitive Disorders |
| Volume | 46 |
| Issue number | 3-4 |
| DOIs | |
| Publication status | Published - Nov 1 2018 |
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Keywords
- Alzheimer's disease
- Amnestic mild cognitive impairment
- Incidence
- Late-life depression
ASJC Scopus subject areas
- Geriatrics and Gerontology
- Cognitive Neuroscience
- Psychiatry and Mental health
Cite this
Late-life depression versus amnestic mild cognitive impairment : Alzheimer's disease incidence in 4 years of follow-up. / Lauriola, Michele; Mangiacotti, Antonio; D'Onofrio, Grazia; Cascavilla, Leandro; Paris, Francesco; Ciccone, Filomena; Greco, Monica; Paroni, Giulia; Seripa, Davide; Greco, Antonio.
In: Dementia and Geriatric Cognitive Disorders, Vol. 46, No. 3-4, 01.11.2018, p. 140-153.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Late-life depression versus amnestic mild cognitive impairment
T2 - Alzheimer's disease incidence in 4 years of follow-up
AU - Lauriola, Michele
AU - Mangiacotti, Antonio
AU - D'Onofrio, Grazia
AU - Cascavilla, Leandro
AU - Paris, Francesco
AU - Ciccone, Filomena
AU - Greco, Monica
AU - Paroni, Giulia
AU - Seripa, Davide
AU - Greco, Antonio
PY - 2018/11/1
Y1 - 2018/11/1
N2 - Background/Aim: The aim of the study was to evaluate the prognostic power of late-life depression (LLD) compared with amnestic mild cognitive impairment (aMCI) for the onset of Alzheimer's disease (AD) within 4 years of follow-up. Methods: We estimated the incidence of AD in 60 patients presenting with aMCI, 115 patients suffering of LLD treated with antidepressants with good compliance, and 66 healthy control (HC) patients, followed for 4 years. Results: The risk to develop AD, within 4 years, was 68.33% for aMCI and 49.57% for LLD. In AD patients 5.60% deteriorated without depression, and 72.20% deteriorated with depression after 4 years of follow-up (p < 0.0001). No HC patients deteriorated to AD or any other dementia type. Conclusion: In our results, aMCI was the first predictive condition that increased the risk to develop AD. Depression is a potentially preventable medical condition across the lifespan and may be a modifiable risk factor.
AB - Background/Aim: The aim of the study was to evaluate the prognostic power of late-life depression (LLD) compared with amnestic mild cognitive impairment (aMCI) for the onset of Alzheimer's disease (AD) within 4 years of follow-up. Methods: We estimated the incidence of AD in 60 patients presenting with aMCI, 115 patients suffering of LLD treated with antidepressants with good compliance, and 66 healthy control (HC) patients, followed for 4 years. Results: The risk to develop AD, within 4 years, was 68.33% for aMCI and 49.57% for LLD. In AD patients 5.60% deteriorated without depression, and 72.20% deteriorated with depression after 4 years of follow-up (p < 0.0001). No HC patients deteriorated to AD or any other dementia type. Conclusion: In our results, aMCI was the first predictive condition that increased the risk to develop AD. Depression is a potentially preventable medical condition across the lifespan and may be a modifiable risk factor.
KW - Alzheimer's disease
KW - Amnestic mild cognitive impairment
KW - Incidence
KW - Late-life depression
UR - http://www.scopus.com/inward/record.url?scp=85053803461&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85053803461&partnerID=8YFLogxK
U2 - 10.1159/000492489
DO - 10.1159/000492489
M3 - Article
C2 - 30199883
AN - SCOPUS:85053803461
VL - 46
SP - 140
EP - 153
JO - Dementia and Geriatric Cognitive Disorders
JF - Dementia and Geriatric Cognitive Disorders
SN - 1420-8008
IS - 3-4
ER -