Late local treatment morbidity after accelerated radiotherapy or alternating chemoradiotherapy for advanced head and neck carcinoma

Giuseppe Sanguineti, Maria Pia Sormani, Marco Benasso, Renzo Corvò, Franca Foppiano, Isabella Ricci, Michela Marcenaro, Riccardo Rosso, Vito Vitale

Research output: Contribution to journalArticle

Abstract

Background: To report local long-term morbidity after concomitant boost radiotherapy (AFRT) or alternating chemoradiotherapy (CTRT), we analyzed the toxicity data recorded in 168 patients with advanced head and neck squamous cell carcinoma treated at our institution within phase II-III studies. Patients and methods: All patients enrolled in three consecutive phase II-III studies and followed for a minimum of three months after the end of treatment were included in the present analysis. Local late reactions were scored prospectively. The actuarial incidence of grade 2 or more (2-4) late local toxicity according to RTOG/EORTC was taken as endpoint. The median follow-up is 32.0 months (range, 3.3-138.1 months). For living patients the minimum and median follow-up are 12.1 and 69.3 months, respectively. Results: The five-year actuarial incidence of grade 2+ and grade 3+ toxicity are 56.7 ± 5% and 21 ± 4%, respectively. At multivariate analysis, acute mucositis grade, complementary surgery, primary site and performance status proved to be independent predictive factors of grade 2+ late toxicity with P values of

Original languageEnglish
Pages (from-to)313-320
Number of pages8
JournalTumori
Volume88
Issue number4
Publication statusPublished - Jul 2002

Keywords

  • Chemotherapy
  • Head and neck carcinoma
  • Late toxicity
  • Radiotherapy

ASJC Scopus subject areas

  • Cancer Research

Fingerprint Dive into the research topics of 'Late local treatment morbidity after accelerated radiotherapy or alternating chemoradiotherapy for advanced head and neck carcinoma'. Together they form a unique fingerprint.

  • Cite this

    Sanguineti, G., Sormani, M. P., Benasso, M., Corvò, R., Foppiano, F., Ricci, I., Marcenaro, M., Rosso, R., & Vitale, V. (2002). Late local treatment morbidity after accelerated radiotherapy or alternating chemoradiotherapy for advanced head and neck carcinoma. Tumori, 88(4), 313-320.