Extramedullary manifestation of multiple myeloma (MMy) is relatively frequent. Macroscopic and microscopic involvement of extra-skeletal sites has been reported in 65-70 per cent of MMy cases at postmorten examination. The spleen, liver, lymph nodes and kidney are the commonest sites affected; the adrenals, thyroid, lungs, skin, soft tissues and pancreas may also be involved, but less frequently. Occacionally, plasmacytomas arise in extra-osseous sites, most commonly in the upper airways, such as the nasal cavities, sinuses, nasopharynx and larynx. Many of these patients eventually develop skeletal manifestations and may exhibit the clinical picture of a MMy usually with monoclonal IgG or IgA production. IgD myeloma is sufficiently distinct from other sub-groups of MMy and it is relatively uncommon, representing only 0.6 to 3 per cent of all cases of MMy. This report deals with a case of IgD myeloma occurring in a 45 year old man with a long-standing history of extramedullary plasmacytoma (EMP) involving the nasal cavity, a cervical lymph node and the larynx.
|Number of pages||8|
|Journal||Journal of Laryngology and Otology|
|Publication status||Published - 1982|
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