Late-onset neonatal group B streptococcal disease associated with breast milk transmission: Molecular typing using RAPD-PCR

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Abstract

Group B Streptococcus (GBS) is considered to be the major cause of neonatal sepsis and meningitis of bacterial origin. Late-onset GBS infection is infrequent and occurs between 1 week and 3 months of age. The transmission of GBS through the ingestion of breast milk is reported in the literature, but only a few of these cases have been confirmed by molecular techniques. In this article we report five cases of late-onset GBS disease: transmission through maternal milk was confirmed in four cases, using the random amplified polymorphic DNA polymerase chain reaction (RAPD-PCR) typing assay. In addition, the RAPD-PCR assay showed that each of the isolated clones belonged to a different RAPD genotype, thus revealing that the late-onset GBS infections were not epidemiologically related.

Original languageEnglish
JournalEarly Human Development
Volume90
Issue numberSUPPL.1
DOIs
Publication statusPublished - 2014

Keywords

  • Breast milk transmission
  • Group B streptococcal disease
  • Random amplified polymorphic DNA (RAPD)

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology
  • Medicine(all)

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