Abstract
Group B Streptococcus (GBS) is considered to be the major cause of neonatal sepsis and meningitis of bacterial origin. Late-onset GBS infection is infrequent and occurs between 1 week and 3 months of age. The transmission of GBS through the ingestion of breast milk is reported in the literature, but only a few of these cases have been confirmed by molecular techniques. In this article we report five cases of late-onset GBS disease: transmission through maternal milk was confirmed in four cases, using the random amplified polymorphic DNA polymerase chain reaction (RAPD-PCR) typing assay. In addition, the RAPD-PCR assay showed that each of the isolated clones belonged to a different RAPD genotype, thus revealing that the late-onset GBS infections were not epidemiologically related.
| Original language | English |
|---|---|
| Journal | Early Human Development |
| Volume | 90 |
| Issue number | SUPPL.1 |
| DOIs | |
| Publication status | Published - 2014 |
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Keywords
- Breast milk transmission
- Group B streptococcal disease
- Random amplified polymorphic DNA (RAPD)
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Obstetrics and Gynaecology
- Medicine(all)
Cite this
Late-onset neonatal group B streptococcal disease associated with breast milk transmission : Molecular typing using RAPD-PCR. / Brandolini, Micaela; Corbella, Marta; Cambieri, Patrizia; Barbarini, Daniela; Sassera, Davide; Stronati, Mauro; Marone, Piero.
In: Early Human Development, Vol. 90, No. SUPPL.1, 2014.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Late-onset neonatal group B streptococcal disease associated with breast milk transmission
T2 - Molecular typing using RAPD-PCR
AU - Brandolini, Micaela
AU - Corbella, Marta
AU - Cambieri, Patrizia
AU - Barbarini, Daniela
AU - Sassera, Davide
AU - Stronati, Mauro
AU - Marone, Piero
PY - 2014
Y1 - 2014
N2 - Group B Streptococcus (GBS) is considered to be the major cause of neonatal sepsis and meningitis of bacterial origin. Late-onset GBS infection is infrequent and occurs between 1 week and 3 months of age. The transmission of GBS through the ingestion of breast milk is reported in the literature, but only a few of these cases have been confirmed by molecular techniques. In this article we report five cases of late-onset GBS disease: transmission through maternal milk was confirmed in four cases, using the random amplified polymorphic DNA polymerase chain reaction (RAPD-PCR) typing assay. In addition, the RAPD-PCR assay showed that each of the isolated clones belonged to a different RAPD genotype, thus revealing that the late-onset GBS infections were not epidemiologically related.
AB - Group B Streptococcus (GBS) is considered to be the major cause of neonatal sepsis and meningitis of bacterial origin. Late-onset GBS infection is infrequent and occurs between 1 week and 3 months of age. The transmission of GBS through the ingestion of breast milk is reported in the literature, but only a few of these cases have been confirmed by molecular techniques. In this article we report five cases of late-onset GBS disease: transmission through maternal milk was confirmed in four cases, using the random amplified polymorphic DNA polymerase chain reaction (RAPD-PCR) typing assay. In addition, the RAPD-PCR assay showed that each of the isolated clones belonged to a different RAPD genotype, thus revealing that the late-onset GBS infections were not epidemiologically related.
KW - Breast milk transmission
KW - Group B streptococcal disease
KW - Random amplified polymorphic DNA (RAPD)
UR - http://www.scopus.com/inward/record.url?scp=84897510627&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84897510627&partnerID=8YFLogxK
U2 - 10.1016/S0378-3782(14)70025-8
DO - 10.1016/S0378-3782(14)70025-8
M3 - Article
C2 - 24709469
AN - SCOPUS:84897510627
VL - 90
JO - Early Human Development
JF - Early Human Development
SN - 0378-3782
IS - SUPPL.1
ER -