Late Persistent Increased Putaminal 18F-DOPA Uptake Following Ipsilateral Frontal Resection: Evidence for Corticostriatal Synaptic Plasticity?

Giovanni Morana, Arnoldo Piccardo, Maria L uisa Garrè, Flavio Nobili, Andrea Rossi

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3 Citations (Scopus)

Abstract

We report the finding of late persistent increased putaminal F-3,4-dihydroxyphenylalanine (DOPA) uptake following resection of a high-grade glioma involving the lateral portion of the ipsilateral precentral gyrus. Brain MRI findings were consistent with secondary putaminal degeneration. This F-DOPA PET phenomenon possibly represents elevated presynaptic dopamine function secondary to upregulation of the amino acid decarboxylase (AADC) activity, as a compensatory mechanism in response to cortical injury. In the setting of brain tumor surveillance, focal increased striatal F-DOPA uptake should be carefully interpreted in light of MRI findings and pathological changes related to corticostriatal connections.

Original languageEnglish
Pages (from-to)e451-e452
JournalClinical Nuclear Medicine
Volume40
Issue number9
DOIs
Publication statusPublished - Sep 1 2015

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Dihydroxyphenylalanine
Neuronal Plasticity
Corpus Striatum
Carboxy-Lyases
Frontal Lobe
Brain Neoplasms
Glioma
Dopamine
Up-Regulation
Amino Acids
Wounds and Injuries
Brain

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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