Late pulmonary effects in favorable stage I and IIA Hodgkin's disease treated with radiotherapy alone

Fabrizio Villani, Simonetta Viviani, Valeria Bonfante, Patrizia De Maria, Fulvia Soncini, A. Laffranchi

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Radiotherapy (RT) in patients with favorable-stage Hodgkin's disease can induce clinical and subclinical evidence of pulmonary damage lasting over the years. In this study, we monitored 36 patients with stage IA-IIA Hodgkin's disease treated with subtotal nodal RT. The planned dose of RT was 40 Gy to 44 Gy to the involved areas and 36 Gy to the adjacent uninvolved areas. Pulmonary function was evaluated by chest radiograph, spirometric parameters, arterial blood gas analysis, and single-breath CO transfer factor (DLCO). The tests were performed before and at the end of irradiation, and during the follow-up 1 and 3 to 5 years after the treatment. At the end of RT, we found a significant decrease of total lung capacity, vital capacity, forced expiratory volume in 1 second, residual volume, and DLCO. Spirometric parameters improved during the follow-up period, whereas the decline of DLCO (-6.4%) was persistent. No correlation was found between mantle RT dose and DLCO changes. Four patients showed a decline of DLCO of >20% from pretreatment values but only one was symptomatic. Our study confirms that RT induces a pulmonary-restrictive disease at a subclinical level that seems to be reversible in the majority of patients.

Original languageEnglish
Pages (from-to)18-21
Number of pages4
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume23
Issue number1
DOIs
Publication statusPublished - Feb 2000

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Hodgkin Disease
Radiotherapy
Lung
Total Lung Capacity
Transfer Factor
Blood Gas Analysis
Residual Volume
Vital Capacity
Forced Expiratory Volume
Carbon Monoxide
Lung Diseases
Thorax

Keywords

  • Hodgkin's disease
  • Lung toxicity
  • Radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Late pulmonary effects in favorable stage I and IIA Hodgkin's disease treated with radiotherapy alone. / Villani, Fabrizio; Viviani, Simonetta; Bonfante, Valeria; De Maria, Patrizia; Soncini, Fulvia; Laffranchi, A.

In: American Journal of Clinical Oncology: Cancer Clinical Trials, Vol. 23, No. 1, 02.2000, p. 18-21.

Research output: Contribution to journalArticle

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