Late Restenosis Following Sirolimus-Eluting Stent Implantation

John Cosgrave, Simon J. Corbett, Gloria Melzi, Rade Babic, Giuseppe G L Biondi-Zoccai, Flavio Airoldi, Alaide Chieffo, Giuseppe M. Sangiorgi, Matteo Montorfano, Iassen Michev, Mauro Carlino, Antonio Colombo

Research output: Contribution to journalArticlepeer-review


Despite encouraging results from randomized trials, concerns exist about long-term results of sirolimus-eluting stent implantation. We sought to determine whether in-stent restenosis occurring >1 year ("late") after sirolimus-eluting stent implantation is a real clinical entity. We analyzed data on all sirolimus-eluting stents implanted in our institution before March 2003. During the study period 928 lesions in 433 patients were treated. Angiographic follow-up was performed in 306 patients (70.6%) with 679 lesions (73.2%). Angiography after 1 year was performed only in symptomatic patients. We considered restenosis "early" if it occurred during the first year and late if after 1 year. Late restenosis required demonstration of a widely patent stent at 6 to 9 months, with repeat angiography after 1 year demonstrating restenosis. Restenosis occurred in 160 lesions overall (23.5%). Of the 31 (4.6%) that were documented after 1 year, 13 were excluded from analysis due to absence of 6- to 9-month angiography; the remaining 18 (2.6%, 1.7 to 4.2) fulfilled our criteria for late restenosis (median time of documentation 607 days, interquartile range 511 to 923). In conclusion, late restenosis is an infrequent but real entity; its existence implies we should not discount the possibility of restenosis as the cause of symptoms that develop >1 year after sirolimus-eluting stent implantation.

Original languageEnglish
Pages (from-to)41-44
Number of pages4
JournalThe American Journal of Cardiology
Issue number1
Publication statusPublished - Jul 1 2007

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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