Late sarcoma development after curettage and bone grafting of benign bone tumors

Piero Picci, Gabriela Sieberova, Marco Alberghini, Alba Balladelli, Daniel Vanel, Pancras C W Hogendoorn, Mario Mercuri

Research output: Contribution to journalArticle

Abstract

Background and aim: Rarely sarcomas develop in previous benign lesions, after a long term disease free interval. We report the experience on these rare cases observed at a single Institution. Patients and methods: 12 cases curetted and grafted, without radiotherapy developed sarcomas, between 1970 and 2005, 6.5-28 years from curettage (median 18, average 19). Age ranged from 13 to 55 years (median 30, average 32) at first diagnosis; tumors were located in the extremities (9 GCT, benign fibrous histiocytoma, ABC, and solitary bone cyst). Radiographic and clinic documentation, for the benign and malignant lesions, were available. Histology was available for 7 benign and all malignant lesions. Results: To fill cavities, autogenous bone was used in 4 cases, allograft in 2, allograft and tricalcium-phosphate/hydroxyapatite in 1, autogenous/allograft in 1, heterogenous in 1. For 3 cases the origin was not reported. Secondary sarcomas, all high grade, were 8 osteosarcoma, 3 malignant fibrous histiocytoma, and 1 fibrosarcoma. Conclusions: Recurrences with progression from benign tumors are possible, but the very long intervals here reported suggest a different cancerogenesis for these sarcomas. This condition is extremely rare accounting for only 0.26% of all malignant bone sarcomas treated in the years 1970-2005 and represents only 8.76% of all secondary bone sarcomas treated in the same years. This incidence is the same as that of sarcomas arising on fibrous dysplasia, and is lower than those arising on bone infarcts or on Paget's disease. This possible event must be considered during follow-up of benign lesions.

Original languageEnglish
Pages (from-to)19-25
Number of pages7
JournalEuropean Journal of Radiology
Volume77
Issue number1
DOIs
Publication statusPublished - 2011

Keywords

  • Bone grafts
  • Mesenchymal stem cell
  • Secondary sarcomas

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Picci, P., Sieberova, G., Alberghini, M., Balladelli, A., Vanel, D., Hogendoorn, P. C. W., & Mercuri, M. (2011). Late sarcoma development after curettage and bone grafting of benign bone tumors. European Journal of Radiology, 77(1), 19-25. https://doi.org/10.1016/j.ejrad.2010.06.053