Sequenze terminali del ciclo di replicazione di citomegalovirus umano in cellule diploidi Studio ultrastrutturale

Translated title of the contribution: Late stages in the replicative cycle of human cytomegaloviruses in diploid cells. Ultrastructural study

G. Gerna, M. T. Gerna, M. Gullino, G. Achilli

Research output: Contribution to journalArticlepeer-review

Abstract

An ultrastructural study of late stages of the replicative cycle of human cytomegalovirus (CMV) in human embryo fibroblasts cell cultures has been performed. Nucleocapsids are observed only inside the intranuclear inclusion. They mature apparently by taking the envelope from the structural components of microvescicular systems reaching from the nuclear membrane the periphery of the nuclear inclusion. However, some capsids reach "naked" the cytoplasm and then take the envelope from cytoplasmic membranes. In the cytoplasm homogeneous "dense material" and "dense microbodies" are present; in extracellular space enveloped "dense microbodies" are scattered among virions. The peculiar envelopment of CMV capsids, not yet described in the literature, is discussed and the typical ultrastructural cytopathology of CMV infected cells is indicated as an useful tool in diagnostic virology.

Translated title of the contributionLate stages in the replicative cycle of human cytomegaloviruses in diploid cells. Ultrastructural study
Original languageItalian
Pages (from-to)859-871
Number of pages13
JournalAnnali Sclavo; rivista di microbiologia e di immunologia
Volume17
Issue number6
Publication statusPublished - Nov 1975

ASJC Scopus subject areas

  • Medicine(all)

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