Latent AKI is... still AKI: The quantification of the burden of renal dysfunction

Zaccaria Ricci, Stefano Romagnoli, Luca Di Chiara

Research output: Contribution to journalArticlepeer-review


The association between pediatric cardiac surgery, acute kidney injury (AKI), and clinical outcomes has been studied several times in the recent literature. In this issue of Critical Care an interesting and original study analyzed the path from causal AKI entities to clinical AKI consequences through the application of structural equation modeling. The authors described the complex connections linking duration of cardiopulmonary bypass, cross clamp-time, and descriptors of low cardiac output syndrome to AKI modeled as a complex variable composed of post-operative serum creatinine increase of 50% over baseline, urine output <0.5ml/kg/h, and urine creatinine-normalized neutrophil gelatinase lipocalin within 12h of surgery. Similarly, the causal relationships between AKI and hard outcomes in the analyzed population were verified and quantified. The authors, for the first time, produce a repeatable coefficient (0.741) that may become a useful quality benchmark and could be applied to test future interventions aiming to reduce the burden of AKI on children's clinical course.

Original languageEnglish
Article number238
JournalCritical Care
Issue number1
Publication statusPublished - Aug 26 2016


  • Acute kidney injury
  • Cardiopulmonary bypass
  • Congenital heart disease
  • Neutrophil gelatinase associated lipocalin

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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