Latent tuberculosis infection and associated risk factors among undergraduate healthcare students in Italy: A cross-sectional study

Paolo Durando, Giovanni Sotgiu, Fabio Spigno, Mauro Piccinini, Giovanni Mazzarello, Claudio Viscoli, Francesco Copello, Alessandro Poli, Filippo Ansaldi, Giancarlo Icardi

Research output: Contribution to journalArticle

Abstract

Background: The screening of both healthcare workers and students attending teaching hospitals for latent tuberculosis infection (LTBI) is recommended in hospitals of many countries with a low-incidence of TB, including Italy, as a fundamental tool of tuberculosis (TB) control programs. The aim of the study was to estimate the prevalence of LTBI and evaluate the main risk-factors associated with this condition in a cohort of healthcare Italian students.Methods: In a cross-sectional study, performed between January and May 2012, 881 undergraduate students attending the Medical, Nursing, Pediatric Nursing and Midwifery Schools of the University of Genoa, trained at the IRCCS San Martino-IST Teaching Hospital of Genoa, were actively called to undergo the Tuberculin Skin Test (TST). All the TST positive cases were also tested with an Interferon-Gamma Release Assay (IGRA) to confirm the diagnosis of LTBI. A standardized questionnaire was collected for risk-assessment analysis.Results: Seven hundred and thirty-three (83.2%) subjects underwent TST testing. The prevalence of TST positives was 1.4%, and in 4 (0.5%) out of 10 TST positive cases LTBI diagnosis was confirmed by IGRA. No difference in the prevalence of subjects who tested positive to TST emerged between pre-clinical (n = 138) and clinical (n = 595) students. No statistically significant association between TST positivity and age, gender, and BCG vaccination was observed. The main independent variable associated with TST positivity was to be born in a country with a high TB incidence (i.e., ≥20 cases per 100,000 population) (adjusted OR 102.80, 95% CI 18.09-584.04, p <0.001).Conclusions: The prevalence of LTBI among healthcare students resulted very low. The only significant association between TST positivity and potential risk factors was to be born in high TB incidence areas. In countries with a low incidence of TB, the screening programs of healthcare students before clinical training can be useful for the early identification and treatment of the sporadic cases of LTBI.

Original languageEnglish
Article number443
JournalBMC Infectious Diseases
Volume13
Issue number1
DOIs
Publication statusPublished - Sep 23 2013

Keywords

  • Healthcare students
  • Interferon-gamma release assay
  • Latent tuberculosis infection
  • Risk-factors
  • Tuberculin skin test
  • Tuberculosis

ASJC Scopus subject areas

  • Infectious Diseases

Fingerprint Dive into the research topics of 'Latent tuberculosis infection and associated risk factors among undergraduate healthcare students in Italy: A cross-sectional study'. Together they form a unique fingerprint.

  • Cite this

    Durando, P., Sotgiu, G., Spigno, F., Piccinini, M., Mazzarello, G., Viscoli, C., Copello, F., Poli, A., Ansaldi, F., & Icardi, G. (2013). Latent tuberculosis infection and associated risk factors among undergraduate healthcare students in Italy: A cross-sectional study. BMC Infectious Diseases, 13(1), [443]. https://doi.org/10.1186/1471-2334-13-443