Latent tuberculous infection among foreign-born individuals applying to shelters in the metropolitan area of Milan

L Barcellini, D Campisi, PF Castellotti, F Cugnata, G Ferrara, M Ferrarese, N Murgia, A Repossi, DM Cirillo, LR Codecasa

Research output: Contribution to journalArticlepeer-review

Abstract

SETTING: Screening for latent tuberculous infection (LTBI) of groups at high risk of active tuberculosis (TB) is a key component of the End TB Strategy. OBJECTIVES: To conduct a retrospective descriptive analysis of LTBI rates among foreign-born individuals applying to shelters in the metropolitan area of Milan, Italy. DESIGN: All foreign-born individuals registering for accommodation centres in the city of Milan from November 2009 to April 2017 were screened for active TB and LTBI. Individuals aged,36 years with a tuberculin skin test (TST) induration of .10 mm were offered confirmatory testing with QuantiFERONw-TB Gold In-Tube (QFT-GIT). RESULTS: Of the 2666 TST-positive migrants aged,36 years who underwent LTBI confirmation testing, 1322 (49.6%) tested negative, 1339 (50.2%) were positive and five (0.2%) had indeterminate results. In the multivariate analysis, TB incidence in the country of origin and age were significantly associated with QFT-GIT positivity. Although estimated TB incidence in Eritrea, Morocco and Romania was 6100/100 000 person-years (py), the probability of being QFT-GIT-positive in individuals from these countries were not statistically significantly different from individuals from countries with TB incidence . 250/100 000 person-years. CONCLUSIONS: Our data showed a high proportion of LTBI among individuals coming from intermediate TB burden countries. © 2018 International Union against Tubercul. and Lung Dis.. All rights reserved.
Original languageEnglish
Pages (from-to)1160-1165
Number of pages6
JournalInternational Journal of Tuberculosis and Lung Disease
Volume22
Issue number10
DOIs
Publication statusPublished - 2018

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