Lateral gaze nystagmus in carbamazepine-treated epileptic patients: Correlation with total and free plasma concentrations of parent drug and its 10,11-epoxide metabolite

R. Riva, M. Contin, F. Albani, E. Perucca, G. Ambrosetto, G. Procaccianti, M. Santucci, A. Baruzzi

Research output: Contribution to journalArticlepeer-review

Abstract

The incidence of lateral gaze nystagmus and its correlation with free and total plasma concentrations of carbamazepine (CBZ) and carbamazepine -10,11-epoxide (CBZ-E) were examined in 97 epileptic patients receiving chronic treatment with CBZ alone (n = 54) or in combination with phenobarbital (PB) (n = 43). All patients had plasma CBZ concentrations within the clinically optimal range (

Original languageEnglish
Pages (from-to)277-282
Number of pages6
JournalTherapeutic Drug Monitoring
Volume7
Issue number3
Publication statusPublished - 1985

Keywords

  • 11 –epoxide
  • Carbamazepine
  • Carbamazepine-10
  • Drug interaction
  • Nystagmus

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Toxicology
  • Health, Toxicology and Mutagenesis
  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Public Health, Environmental and Occupational Health

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