Lateral gaze nystagmus in carbamazepine-treated epileptic patients: Correlation with total and free plasma concentrations of parent drug and its 10,11-epoxide metabolite

R. Riva; M. Contin; F. Albani; E. Perucca; G. Ambrosetto; G. Procaccianti; M. Santucci; A. Baruzzi

Lateral gaze nystagmus in carbamazepine-treated epileptic patients: Correlation with total and free plasma concentrations of parent drug and its 10,11-epoxide metabolite

R. Riva, M. Contin, F. Albani, E. Perucca, G. Ambrosetto, G. Procaccianti, M. Santucci, A. Baruzzi

Research output: Contribution to journal › Article › peer-review

Abstract

The incidence of lateral gaze nystagmus and its correlation with free and total plasma concentrations of carbamazepine (CBZ) and carbamazepine -10,11-epoxide (CBZ-E) were examined in 97 epileptic patients receiving chronic treatment with CBZ alone (n = 54) or in combination with phenobarbital (PB) (n = 43). All patients had plasma CBZ concentrations within the clinically optimal range (

Original language	English
Pages (from-to)	277-282
Number of pages	6
Journal	Therapeutic Drug Monitoring
Volume	7
Issue number	3
Publication status	Published - 1985

Keywords

11 –epoxide
Carbamazepine
Carbamazepine-10
Drug interaction
Nystagmus

ASJC Scopus subject areas

Pharmacology (medical)
Pharmacology
Toxicology
Health, Toxicology and Mutagenesis
Biochemistry
Biochemistry, Genetics and Molecular Biology(all)
Public Health, Environmental and Occupational Health

Cite this

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AU - Riva, R.

AU - Contin, M.

AU - Albani, F.

AU - Perucca, E.

AU - Ambrosetto, G.

AU - Procaccianti, G.

AU - Santucci, M.

AU - Baruzzi, A.

PY - 1985

Y1 - 1985

N2 - The incidence of lateral gaze nystagmus and its correlation with free and total plasma concentrations of carbamazepine (CBZ) and carbamazepine -10,11-epoxide (CBZ-E) were examined in 97 epileptic patients receiving chronic treatment with CBZ alone (n = 54) or in combination with phenobarbital (PB) (n = 43). All patients had plasma CBZ concentrations within the clinically optimal range (

AB - The incidence of lateral gaze nystagmus and its correlation with free and total plasma concentrations of carbamazepine (CBZ) and carbamazepine -10,11-epoxide (CBZ-E) were examined in 97 epileptic patients receiving chronic treatment with CBZ alone (n = 54) or in combination with phenobarbital (PB) (n = 43). All patients had plasma CBZ concentrations within the clinically optimal range (

KW - 11 –epoxide

KW - Carbamazepine

KW - Carbamazepine-10

KW - Drug interaction

KW - Nystagmus

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Lateral gaze nystagmus in carbamazepine-treated epileptic patients: Correlation with total and free plasma concentrations of parent drug and its 10,11-epoxide metabolite

Abstract

Keywords

ASJC Scopus subject areas

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