Lateral inhibition in visual cortex of migraine patients between attacks.

Gianluca Coppola, Vincenzo Parisi, Cherubino Di Lorenzo, Mariano Serrao, Delphine Magis, Jean Schoenen, Francesco Pierelli

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Abstract

The interictal deficit of habituation to repetitive visual stimuli in migraine patients could be due to deficient intracortical inhibition and/or to low cortical pre-activation levels. Which of these abnormalities contributes more to the habituation deficit cannot be determined with the common methods used to record transient visual responses.We investigated lateral inhibition in the visual cortex during the migraine cycle and in healthy subjects by using differential temporal modulations of radial windmill-dartboard (WD) or partial-windmill (PW) visual patterns. Transient (TR-VEP) and steady-state visual-evoked potentials (SS-VEP) were recorded in 65 migraine patients (21 without and 22 with aura between attacks; 22 patients during an attack) and in 21 healthy volunteers (HV). Three stimulations were used in each subject: classic checkerboard pattern (contrast-reversion 3.1 Hz), WD and PW (contrast-reversion ~4 Hz). For each randomly presented stimulation protocol, 600 sweeps were acquired and off-line partitioned in 6 blocks of 100. Fourier analysis allowed data to extract in SS-VEP the fundamental (1H) and the second harmonic (2H) components that reflect respectively short-(WD) and long- range lateral inhibition (attenuation of 2H in WD compared to PW). Compared to HV, migraineurs recorded interictally had significantly less habituation of the N1-P1 TR-VEP component over subsequent blocks and they tended to have a smaller 1st block amplitude. 1H amplitude in the 1st block of WD SS-VEP was significantly greater than in HV and habituated in successive blocks, contrasting with an amplitude increase in HV. Both the interictal TR-VEP and SS-VEP abnormalities normalized during an attack. There was no significant between group difference in the PW 2H amplitude and its attenuation. When data of HV and migraine patients were combined, the habituation slope of WD-VEP 1H was negatively correlated with that of TR-VEP N1-P1 and with number of days since the last migraine attack. These results are in favour of a migraine cycle-dependent imbalance between excitation and inhibition in the visual cortex. We hypothesize that an interictal hypoactivity of monaminergic pathways may cause a functional disconnection of the thalamus in migraine leading to an abnormal intracortical short-range lateral inhibition that could contribute to the habituation deficit observed during stimulus repetition.

Original languageEnglish
Pages (from-to)20
Number of pages1
JournalJournal of Headache and Pain
Volume14
Issue number1
DOIs
Publication statusPublished - Dec 2013

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Visual Cortex
Migraine Disorders
Healthy Volunteers
Visual Evoked Potentials
Fourier Analysis
Thalamus
Epilepsy

ASJC Scopus subject areas

  • Medicine(all)

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Lateral inhibition in visual cortex of migraine patients between attacks. / Coppola, Gianluca; Parisi, Vincenzo; Di Lorenzo, Cherubino; Serrao, Mariano; Magis, Delphine; Schoenen, Jean; Pierelli, Francesco.

In: Journal of Headache and Pain, Vol. 14, No. 1, 12.2013, p. 20.

Research output: Contribution to journalArticle

Coppola, Gianluca ; Parisi, Vincenzo ; Di Lorenzo, Cherubino ; Serrao, Mariano ; Magis, Delphine ; Schoenen, Jean ; Pierelli, Francesco. / Lateral inhibition in visual cortex of migraine patients between attacks. In: Journal of Headache and Pain. 2013 ; Vol. 14, No. 1. pp. 20.
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