Laterality in persons with intellectual disability II. Hand, foot, ear, and eye laterality in persons with trisomy 21 and Williams-Beuren syndrome

Aude Gérard-Desplanches, Christine Deruelle, Silvia Stefanini, Catherine Ayoun, Virginia Volterra, Stefano Vicari, Gene Fisch, Michèle Carlier

Research output: Contribution to journalArticle


Laterality (hand, foot, ear, and eye) was assessed in participants with Trisomy 21 (62) and Williams-Beuren syndrome (WBS) (39). Handedness was also assessed in a card reaching task. The comparison group included 184 typically developing persons. Two independent age sub-groups were formed: 7 to 10 years old and 11 to 34 years old. We confirmed previous data: individuals with T21 were more frequently left- or mixed-handed than typically developing persons; individuals with WBS had intermediate scores. The two groups with genetic disorders had less right foot preference. Manual and foot inconsistencies characterized both groups with genetic disorders. Cross hand-foot preference was lower in the typically developing group. Differences in IQ levels did not correlate with differences in laterality scores. Overall laterality profiles were not the same in the two groups with genetic disorders: the greatest differences were observed between typically developing persons and persons with Trisomy 21.

Original languageEnglish
Pages (from-to)482-491
Number of pages10
Issue number6
Publication statusPublished - Sep 2006



  • Footedness
  • Genetic disorders
  • Handedness
  • Trisomy 21
  • Williams-Beuren syndrome

ASJC Scopus subject areas

  • Developmental Biology
  • Embryology
  • Psychology(all)

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