Laterality preference and cognition: Cross-syndrome comparison of patients with trisomy 21 (Down), del7q11.23 (Williams-Beuren) and del22q11.2 (DiGeorge or Velo-Cardio-Facial) syndromes

Michèle Carlier, Aude Gérard Desplanches, Nicole Philip, Silvia Stefanini, Stefano Vicari, Virginia Volterra, Christine Deruelle, Gene Fisch, Anne Lise Doyen, Anne Swillen

Research output: Contribution to journalArticlepeer-review

Abstract

We report on a cross-syndrome comparison of hand, foot, eye and ear laterality in three groups of individuals with different genetic disorders (trisomy 21, del7q11.23, and del22q11.2) to test the relationship between atypical laterality and intellectual disability. These groups were compared to a group of typically developing persons. Hand, foot, eye and ear laterality was assessed using item tasks, conducted twice, and Bishop's card-reaching test. Ordering of the mean IQ score for each of the three groups was as follows: trisomy 21 <del7q11.23 <del22q11.2. We observed the same ordering as for IQ, particularly in mixed handedness, degree of laterality, hand and foot consistency. The existence of a cognitive threshold, below which lateral preference is atypical, advocates for a causal link between cognition and laterality in those with low IQ although unknown other factors underlying both could determine this association.

Original languageEnglish
Pages (from-to)413-422
Number of pages10
JournalBehavior Genetics
Volume41
Issue number3
DOIs
Publication statusPublished - May 2011

Keywords

  • Ambiguous laterality
  • Cognition
  • Genetic disorders
  • Handedness
  • Intellectual disability
  • IQ
  • Left-handedness
  • Mental retardation

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Ecology, Evolution, Behavior and Systematics

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