Lateralization of expression of neural sympathetic activity to the vessels and effects of carotid baroreceptor stimulation

Andreá Diedrich, Alberto Porta, Franca Barbic, Robert J. Brychta, Pietro Bonizzi, Laura Diedrich, Sergio Cerutti, David Robertson, Raffaello Furlan

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Human studies suggest that cardiovascular neural sympathetic control is predominantly modulated by the right cerebral hemisphere. It is unknown whether post-ganglionic sympathetic activity [muscle sympathetic nerve activity (MSNA)] shows any functional asymmetry. Eight right-handed volunteers (3 women and 5 men, 32 ± 2 yr of age) underwent ECG, beat-by-beat blood pressure, respiratory activity, and simultaneous right and left MSNA recordings during spontaneous and controlled breathing (CB, 15 breaths/min, 0.25 Hz). Dynamic carotid baroreceptor stimulation was obtained by 0.1-Hz sinusoidal suction, from 0 to -50 mmHg, randomly applied to the right, left, and combined right and left sides of the neck during CB. Laterality was assessed by changes in the MSNA burst rate (in bursts/min, and bursts/100 beats), strength [amplitude (A) and area (AA)], and the oscillatory component at 0.1 Hz during baroreceptor stimulation. Amplitude parameters were normalized by CB burst mean amplitude and area of the same side. At rest, the right and left MSNA burst rate and total MSNA activity were similar. Conversely, the right MSNA normalized burst A N (1.36 ± 0.18) and AA N (1.31 ± 0.16) were larger than the left MSNA A N (1.04 ± 0.09) and AA N (1.02 ± 0.08). Unilateral and bilateral carotid baroreflex stimulation abolished the right prevalence of A N and AA N. In conclusion, the right lateralization of sympathetic activity to the vessels is indicated by normalized burst strength parameters of bilateral MSNA recordings at rest during spontaneous breathing. Carotid baroreceptor stimulation disrupted such expression of MSNA lateralization possibly by disturbing the synchronizing action of right cerebral hemisphere.

Original languageEnglish
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume296
Issue number6
DOIs
Publication statusPublished - Jun 2009

Fingerprint

Pressoreceptors
Muscles
Cerebrum
Respiration
Baroreflex
Suction
Volunteers
Electrocardiography
Neck
Blood Pressure

Keywords

  • Area
  • Burst amplitude
  • Laterality
  • Muscle sympathetic nerve activity recording
  • Sympathetic control of circulation

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

Lateralization of expression of neural sympathetic activity to the vessels and effects of carotid baroreceptor stimulation. / Diedrich, Andreá; Porta, Alberto; Barbic, Franca; Brychta, Robert J.; Bonizzi, Pietro; Diedrich, Laura; Cerutti, Sergio; Robertson, David; Furlan, Raffaello.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 296, No. 6, 06.2009.

Research output: Contribution to journalArticle

@article{3119df4d5f3641a49da5068fc21d569b,
title = "Lateralization of expression of neural sympathetic activity to the vessels and effects of carotid baroreceptor stimulation",
abstract = "Human studies suggest that cardiovascular neural sympathetic control is predominantly modulated by the right cerebral hemisphere. It is unknown whether post-ganglionic sympathetic activity [muscle sympathetic nerve activity (MSNA)] shows any functional asymmetry. Eight right-handed volunteers (3 women and 5 men, 32 ± 2 yr of age) underwent ECG, beat-by-beat blood pressure, respiratory activity, and simultaneous right and left MSNA recordings during spontaneous and controlled breathing (CB, 15 breaths/min, 0.25 Hz). Dynamic carotid baroreceptor stimulation was obtained by 0.1-Hz sinusoidal suction, from 0 to -50 mmHg, randomly applied to the right, left, and combined right and left sides of the neck during CB. Laterality was assessed by changes in the MSNA burst rate (in bursts/min, and bursts/100 beats), strength [amplitude (A) and area (AA)], and the oscillatory component at 0.1 Hz during baroreceptor stimulation. Amplitude parameters were normalized by CB burst mean amplitude and area of the same side. At rest, the right and left MSNA burst rate and total MSNA activity were similar. Conversely, the right MSNA normalized burst A N (1.36 ± 0.18) and AA N (1.31 ± 0.16) were larger than the left MSNA A N (1.04 ± 0.09) and AA N (1.02 ± 0.08). Unilateral and bilateral carotid baroreflex stimulation abolished the right prevalence of A N and AA N. In conclusion, the right lateralization of sympathetic activity to the vessels is indicated by normalized burst strength parameters of bilateral MSNA recordings at rest during spontaneous breathing. Carotid baroreceptor stimulation disrupted such expression of MSNA lateralization possibly by disturbing the synchronizing action of right cerebral hemisphere.",
keywords = "Area, Burst amplitude, Laterality, Muscle sympathetic nerve activity recording, Sympathetic control of circulation",
author = "Andre{\'a} Diedrich and Alberto Porta and Franca Barbic and Brychta, {Robert J.} and Pietro Bonizzi and Laura Diedrich and Sergio Cerutti and David Robertson and Raffaello Furlan",
year = "2009",
month = "6",
doi = "10.1152/ajpheart.01045.2008",
language = "English",
volume = "296",
journal = "American Journal of Physiology",
issn = "0363-6119",
publisher = "American Physiological Society",
number = "6",

}

TY - JOUR

T1 - Lateralization of expression of neural sympathetic activity to the vessels and effects of carotid baroreceptor stimulation

AU - Diedrich, Andreá

AU - Porta, Alberto

AU - Barbic, Franca

AU - Brychta, Robert J.

AU - Bonizzi, Pietro

AU - Diedrich, Laura

AU - Cerutti, Sergio

AU - Robertson, David

AU - Furlan, Raffaello

PY - 2009/6

Y1 - 2009/6

N2 - Human studies suggest that cardiovascular neural sympathetic control is predominantly modulated by the right cerebral hemisphere. It is unknown whether post-ganglionic sympathetic activity [muscle sympathetic nerve activity (MSNA)] shows any functional asymmetry. Eight right-handed volunteers (3 women and 5 men, 32 ± 2 yr of age) underwent ECG, beat-by-beat blood pressure, respiratory activity, and simultaneous right and left MSNA recordings during spontaneous and controlled breathing (CB, 15 breaths/min, 0.25 Hz). Dynamic carotid baroreceptor stimulation was obtained by 0.1-Hz sinusoidal suction, from 0 to -50 mmHg, randomly applied to the right, left, and combined right and left sides of the neck during CB. Laterality was assessed by changes in the MSNA burst rate (in bursts/min, and bursts/100 beats), strength [amplitude (A) and area (AA)], and the oscillatory component at 0.1 Hz during baroreceptor stimulation. Amplitude parameters were normalized by CB burst mean amplitude and area of the same side. At rest, the right and left MSNA burst rate and total MSNA activity were similar. Conversely, the right MSNA normalized burst A N (1.36 ± 0.18) and AA N (1.31 ± 0.16) were larger than the left MSNA A N (1.04 ± 0.09) and AA N (1.02 ± 0.08). Unilateral and bilateral carotid baroreflex stimulation abolished the right prevalence of A N and AA N. In conclusion, the right lateralization of sympathetic activity to the vessels is indicated by normalized burst strength parameters of bilateral MSNA recordings at rest during spontaneous breathing. Carotid baroreceptor stimulation disrupted such expression of MSNA lateralization possibly by disturbing the synchronizing action of right cerebral hemisphere.

AB - Human studies suggest that cardiovascular neural sympathetic control is predominantly modulated by the right cerebral hemisphere. It is unknown whether post-ganglionic sympathetic activity [muscle sympathetic nerve activity (MSNA)] shows any functional asymmetry. Eight right-handed volunteers (3 women and 5 men, 32 ± 2 yr of age) underwent ECG, beat-by-beat blood pressure, respiratory activity, and simultaneous right and left MSNA recordings during spontaneous and controlled breathing (CB, 15 breaths/min, 0.25 Hz). Dynamic carotid baroreceptor stimulation was obtained by 0.1-Hz sinusoidal suction, from 0 to -50 mmHg, randomly applied to the right, left, and combined right and left sides of the neck during CB. Laterality was assessed by changes in the MSNA burst rate (in bursts/min, and bursts/100 beats), strength [amplitude (A) and area (AA)], and the oscillatory component at 0.1 Hz during baroreceptor stimulation. Amplitude parameters were normalized by CB burst mean amplitude and area of the same side. At rest, the right and left MSNA burst rate and total MSNA activity were similar. Conversely, the right MSNA normalized burst A N (1.36 ± 0.18) and AA N (1.31 ± 0.16) were larger than the left MSNA A N (1.04 ± 0.09) and AA N (1.02 ± 0.08). Unilateral and bilateral carotid baroreflex stimulation abolished the right prevalence of A N and AA N. In conclusion, the right lateralization of sympathetic activity to the vessels is indicated by normalized burst strength parameters of bilateral MSNA recordings at rest during spontaneous breathing. Carotid baroreceptor stimulation disrupted such expression of MSNA lateralization possibly by disturbing the synchronizing action of right cerebral hemisphere.

KW - Area

KW - Burst amplitude

KW - Laterality

KW - Muscle sympathetic nerve activity recording

KW - Sympathetic control of circulation

UR - http://www.scopus.com/inward/record.url?scp=66949154672&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=66949154672&partnerID=8YFLogxK

U2 - 10.1152/ajpheart.01045.2008

DO - 10.1152/ajpheart.01045.2008

M3 - Article

VL - 296

JO - American Journal of Physiology

JF - American Journal of Physiology

SN - 0363-6119

IS - 6

ER -