Lateralization of the epileptogenic focus by computerized eeg study and neuropsychological evaluation

M. G. Marciani, F. Stefanini, N. Stefani, M. C E Maschio, G. L. Gigli, S. Roncacci, C. Caltagirone, G. Bernardi

Research output: Contribution to journalArticlepeer-review


The localization of the epileptopenic focus relies on different factors. In patients with partial seizures, asymmetries in EEG background activity were measured by a statistical evaluation of spectral data. Neurophysiological results were compared with neuropsychological findings and MRI. Fifteen of 22 patients showed asymmetries in EEG background activity. The most prominent abnormality was a statistically significant increase of slow activity observed in 59% of cases. Delta asymmetry coincided with the site of lesions, evidenced by MRI. in 83% of patients; with the site of decreased beta activity in 60% and with the maximum level of spiking activity in 58% of cases. Neuropsychological tests showed a lateralization of the hemispheric function which coincided with delta asymmetry in 33% of patients. These results suggest that the EEG background activity, when compared with other parameters, may represent a useful method in lateralizing the epileptogenic focus.

Original languageEnglish
Pages (from-to)53-60
Number of pages8
JournalInternational Journal of Neuroscience
Issue number1-2
Publication statusPublished - 1992


  • EEG mapping
  • Focal epilepsy
  • Neuropsychology

ASJC Scopus subject areas

  • Neuroscience(all)


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