Linfoadenite laterocervicale tubercolare

Terapia medica, chirurgica ed effetti paradossi

Translated title of the contribution: Laterocervical tubercular lymphadenitis: Medical treatment, surgery and paradoxical upgrading reaction

G. Tornese, A. Tedeschi, D. Codrich, C. Fabris, F. Marchetti

Research output: Contribution to journalArticle

Abstract

We report a case of a 1-year-old girl with persistent fever and enlargement of laterocervical lymph nodes on the left side, fluctuant and with erythematous overlying skin. A positive Mantoux skin test first (induration of 20 mm in 72 hours) and then the DNA amplification by polymerase chain reaction (PCR) as well as the culture confirmed the diagnosis of Mycobacterium tuberculosis complex, in particular M. bovis. Nonetheless, after 1 month of standard mycobacterial regimen (isoniazid, rimpaficin, ethambutol, pyrazlnamide), she developed new lymph nodes on the same and on the opposite side, apart from the residual ones. She underwent surgery three times (excision of a lymph node, incision and drainage of the others) for the definitive diagnosis and for the excessive enlargement of the nodes with risk of compression of underlying structures and diffusion. A drug resistance was ruled out by antibiogram. Paradoxical upgrading reaction (PUR) to the therapy offers a plausible explanation for this phenomenon, and this is supported by a prompt answer to steroids.

Original languageItalian
Pages (from-to)51-52
Number of pages2
JournalMedico e Bambino
Volume27
Issue number1
Publication statusPublished - Jan 31 2008

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Lymphadenitis
Lymph Nodes
Ethambutol
Isoniazid
Microbial Sensitivity Tests
DNA-Directed DNA Polymerase
Skin Tests
Lymph Node Excision
Mycobacterium tuberculosis
Drug Resistance
Drainage
Fever
Steroids
Polymerase Chain Reaction
Skin
Therapeutics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Linfoadenite laterocervicale tubercolare : Terapia medica, chirurgica ed effetti paradossi. / Tornese, G.; Tedeschi, A.; Codrich, D.; Fabris, C.; Marchetti, F.

In: Medico e Bambino, Vol. 27, No. 1, 31.01.2008, p. 51-52.

Research output: Contribution to journalArticle

Tornese, G. ; Tedeschi, A. ; Codrich, D. ; Fabris, C. ; Marchetti, F. / Linfoadenite laterocervicale tubercolare : Terapia medica, chirurgica ed effetti paradossi. In: Medico e Bambino. 2008 ; Vol. 27, No. 1. pp. 51-52.
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