Latest treatment strategies for membranous nephropathy

Piero Ruggenenti, Paolo Cravedi, Giuseppe Remuzzi

Research output: Contribution to journalArticlepeer-review

Abstract

Thirty to forty percent of patients with idiopatic membranous nephropathy have persistent heavy proteinuria and may progress to end-stage kidney disease in 5 - 15 years. The ideal treatment for these patients is a matter of debate. Several nonspecific immunosuppressive regimens have been suggested with the aim of reducing proteinuria and to improve outcome, but all are burdened by significant toxicity. Therefore, more specific and less toxic therapies are needed. Promising results have been recently obtained with rituximab, a monoclonal antibody against the CD20 antigen of B lymphocytes that is able to deplete these cells and, thus, neoformation of pathogenetic antibodies. Other novel drugs, such as adrenocorticotropic hormone, mycophenolate mofetil and eculizumab have been proposed. This paper reviews the safety/efficacy profile of various agents that have been proposed as therapy for this disease, with particular focus on the latest, more specific and hypothesis-driven approaches.

Original languageEnglish
Pages (from-to)3159-3171
Number of pages13
JournalExpert Opinion on Pharmacotherapy
Volume8
Issue number18
DOIs
Publication statusPublished - Dec 2007

Keywords

  • adrenocorticoticotropic hormone
  • alkylating agent
  • glucocorticoid
  • membranous nephropathy
  • mycophenolate mofetil
  • nephrotic syndrome
  • rituximab

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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