Latex allergy within a cohort of not-at-risk subjects with respiratory symptoms: Prevalence of latex sensitization and assessment of diagnostic tools

Adriano Mari, Enrico Scala, Claudio D'Ambrosio, Heimo Breiteneder, Stefan Wagner

Research output: Contribution to journalArticle

Abstract

Background: Immunoglobluin E (IgE)-mediated hypersensitivity to natural rubber latex (NRL) is a major problem in allergy practice. Currently, the use of skin prick tests (SPTs) with latex extracts and specific IgE detection for the diagnosis of NRL allergy in suspected patients is directed to identification of risk factors. Many cases of NRL allergy remain undiagnosed due to misreporting of symptoms by the patients or lack of proper questions asked by the physician. Materials and Methods: A total of 6,126 subjects referred for respiratory symptoms underwent SPTs with NRL. Positive subjects were resurveyed for exposure to NRL, and specific IgE for NRL extracts and recombinant molecules was determined. Immunoblots of NRL extracts were performed to identify IgE patterns. Results: Forty-six of 3,930 sensitized subjects had a positive SPT with NRL, displaying a prevalence of NRL sensitization of 0.75% for the general and 1.2% for the sensitized population. Eleven out of 46 (23.9%) subjects could be defined as NRL asymptomatic, whereas 35 (76.1%) developed symptoms upon exposure to NRL. Specific IgE to NRL was detected for 22 (75.86%) of 29 tested sera. Seventeen out of 22 (77%) sera displayed specific IgE to recombinant allergens with most reactions to Hev b 5, Hev b 6.01 and Hev b 6.02. Immunoblots of NRL extract fractions with patients' sera showed heterogeneous patterns. Conclusions: SPTs with NRL extract should be routinely performed in patients with respiratory symptoms. Hev b 5, Hev b 6.01 and Hev b 6.02 are the most important allergens, but further characterization of NRL extracts is needed to identify novel allergens and to clarify the role of crossreactive carbohydrate determinants.

Original languageEnglish
Pages (from-to)135-143
Number of pages9
JournalInternational Archives of Allergy and Immunology
Volume143
Issue number2
DOIs
Publication statusPublished - May 2007

Keywords

  • Asthma
  • Hev b allergens
  • Latex allergy
  • Rhinitis
  • Urticaria

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Latex allergy within a cohort of not-at-risk subjects with respiratory symptoms: Prevalence of latex sensitization and assessment of diagnostic tools'. Together they form a unique fingerprint.

  • Cite this