Abstract
Introduction: The only etiological and decisive therapy, able to influence the natural history of latex allergy is the specific desensitization. Aim: To verify the clinical efficacy and immunological changes determined by latex sublingual immunotherapy in allergic patients who underwent this treatment for at least 3 years. Material and methods: We enrolled 76 patients (16 males and 60 females, mean age 34 years old) with evidence of a natural rubber latex allergy. To assess the effectiveness of the immunotherapy we performed a latex skin prick test, specific IgE and IgG4 and challenge tests before and after at least 3 years of desensitization. Results: We observed a reduction in the mean diameter of the wheal area at the skin prick test and a decrease in latex specific IgE while no significant changes of latex IgG4 values were found. Moreover a reduction of symptoms and scores at the provocation tests were remarked. Conclusions: Although the primary prevention (which still remains the gold standard treatment for patients suffering from the latex allergy) sublingual immunotherapy can be offered with efficacy in addition to symptomatic treatment to selected patients.
| Original language | English |
|---|---|
| Pages (from-to) | 145-150 |
| Number of pages | 6 |
| Journal | Postepy Dermatologii I Alergologii |
| Volume | 35 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Apr 1 2018 |
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Keywords
- Challenge
- Desensitization
- Latex allergy
- Sublingual immunotherapy
ASJC Scopus subject areas
- Immunology and Allergy
- Dermatology
Cite this
Latex immunotherapy : Evidence of effectiveness. / Nucera, Eleonora; Mezzacappa, Simona; Buonomo, Alessandro; Centrone, Michele; Rizzi, Angela; Manicone, Paolo Francesco; Patriarca, Giampiero; Aruanno, Arianna; Schiavino, Domenico.
In: Postepy Dermatologii I Alergologii, Vol. 35, No. 2, 01.04.2018, p. 145-150.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Latex immunotherapy
T2 - Evidence of effectiveness
AU - Nucera, Eleonora
AU - Mezzacappa, Simona
AU - Buonomo, Alessandro
AU - Centrone, Michele
AU - Rizzi, Angela
AU - Manicone, Paolo Francesco
AU - Patriarca, Giampiero
AU - Aruanno, Arianna
AU - Schiavino, Domenico
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Introduction: The only etiological and decisive therapy, able to influence the natural history of latex allergy is the specific desensitization. Aim: To verify the clinical efficacy and immunological changes determined by latex sublingual immunotherapy in allergic patients who underwent this treatment for at least 3 years. Material and methods: We enrolled 76 patients (16 males and 60 females, mean age 34 years old) with evidence of a natural rubber latex allergy. To assess the effectiveness of the immunotherapy we performed a latex skin prick test, specific IgE and IgG4 and challenge tests before and after at least 3 years of desensitization. Results: We observed a reduction in the mean diameter of the wheal area at the skin prick test and a decrease in latex specific IgE while no significant changes of latex IgG4 values were found. Moreover a reduction of symptoms and scores at the provocation tests were remarked. Conclusions: Although the primary prevention (which still remains the gold standard treatment for patients suffering from the latex allergy) sublingual immunotherapy can be offered with efficacy in addition to symptomatic treatment to selected patients.
AB - Introduction: The only etiological and decisive therapy, able to influence the natural history of latex allergy is the specific desensitization. Aim: To verify the clinical efficacy and immunological changes determined by latex sublingual immunotherapy in allergic patients who underwent this treatment for at least 3 years. Material and methods: We enrolled 76 patients (16 males and 60 females, mean age 34 years old) with evidence of a natural rubber latex allergy. To assess the effectiveness of the immunotherapy we performed a latex skin prick test, specific IgE and IgG4 and challenge tests before and after at least 3 years of desensitization. Results: We observed a reduction in the mean diameter of the wheal area at the skin prick test and a decrease in latex specific IgE while no significant changes of latex IgG4 values were found. Moreover a reduction of symptoms and scores at the provocation tests were remarked. Conclusions: Although the primary prevention (which still remains the gold standard treatment for patients suffering from the latex allergy) sublingual immunotherapy can be offered with efficacy in addition to symptomatic treatment to selected patients.
KW - Challenge
KW - Desensitization
KW - Latex allergy
KW - Sublingual immunotherapy
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UR - http://www.scopus.com/inward/citedby.url?scp=85046678246&partnerID=8YFLogxK
U2 - 10.5114/ada.2018.75235
DO - 10.5114/ada.2018.75235
M3 - Article
AN - SCOPUS:85046678246
VL - 35
SP - 145
EP - 150
JO - Postepy Dermatologii I Alergologii
JF - Postepy Dermatologii I Alergologii
SN - 1642-395X
IS - 2
ER -