Latex immunotherapy: Evidence of effectiveness

Eleonora Nucera, Simona Mezzacappa, Alessandro Buonomo, Michele Centrone, Angela Rizzi, Paolo Francesco Manicone, Giampiero Patriarca, Arianna Aruanno, Domenico Schiavino

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Introduction: The only etiological and decisive therapy, able to influence the natural history of latex allergy is the specific desensitization. Aim: To verify the clinical efficacy and immunological changes determined by latex sublingual immunotherapy in allergic patients who underwent this treatment for at least 3 years. Material and methods: We enrolled 76 patients (16 males and 60 females, mean age 34 years old) with evidence of a natural rubber latex allergy. To assess the effectiveness of the immunotherapy we performed a latex skin prick test, specific IgE and IgG4 and challenge tests before and after at least 3 years of desensitization. Results: We observed a reduction in the mean diameter of the wheal area at the skin prick test and a decrease in latex specific IgE while no significant changes of latex IgG4 values were found. Moreover a reduction of symptoms and scores at the provocation tests were remarked. Conclusions: Although the primary prevention (which still remains the gold standard treatment for patients suffering from the latex allergy) sublingual immunotherapy can be offered with efficacy in addition to symptomatic treatment to selected patients.

Original languageEnglish
Pages (from-to)145-150
Number of pages6
JournalPostepy Dermatologii I Alergologii
Volume35
Issue number2
DOIs
Publication statusPublished - Apr 1 2018

Fingerprint

Latex
Latex Hypersensitivity
Immunotherapy
Sublingual Immunotherapy
Skin Tests
Immunoglobulin E
Immunoglobulin G
Primary Prevention
Therapeutics

Keywords

  • Challenge
  • Desensitization
  • Latex allergy
  • Sublingual immunotherapy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Dermatology

Cite this

Nucera, E., Mezzacappa, S., Buonomo, A., Centrone, M., Rizzi, A., Manicone, P. F., ... Schiavino, D. (2018). Latex immunotherapy: Evidence of effectiveness. Postepy Dermatologii I Alergologii, 35(2), 145-150. https://doi.org/10.5114/ada.2018.75235

Latex immunotherapy : Evidence of effectiveness. / Nucera, Eleonora; Mezzacappa, Simona; Buonomo, Alessandro; Centrone, Michele; Rizzi, Angela; Manicone, Paolo Francesco; Patriarca, Giampiero; Aruanno, Arianna; Schiavino, Domenico.

In: Postepy Dermatologii I Alergologii, Vol. 35, No. 2, 01.04.2018, p. 145-150.

Research output: Contribution to journalArticle

Nucera, E, Mezzacappa, S, Buonomo, A, Centrone, M, Rizzi, A, Manicone, PF, Patriarca, G, Aruanno, A & Schiavino, D 2018, 'Latex immunotherapy: Evidence of effectiveness', Postepy Dermatologii I Alergologii, vol. 35, no. 2, pp. 145-150. https://doi.org/10.5114/ada.2018.75235
Nucera E, Mezzacappa S, Buonomo A, Centrone M, Rizzi A, Manicone PF et al. Latex immunotherapy: Evidence of effectiveness. Postepy Dermatologii I Alergologii. 2018 Apr 1;35(2):145-150. https://doi.org/10.5114/ada.2018.75235
Nucera, Eleonora ; Mezzacappa, Simona ; Buonomo, Alessandro ; Centrone, Michele ; Rizzi, Angela ; Manicone, Paolo Francesco ; Patriarca, Giampiero ; Aruanno, Arianna ; Schiavino, Domenico. / Latex immunotherapy : Evidence of effectiveness. In: Postepy Dermatologii I Alergologii. 2018 ; Vol. 35, No. 2. pp. 145-150.
@article{c0c40b066c884209be76dcebc98c7286,
title = "Latex immunotherapy: Evidence of effectiveness",
abstract = "Introduction: The only etiological and decisive therapy, able to influence the natural history of latex allergy is the specific desensitization. Aim: To verify the clinical efficacy and immunological changes determined by latex sublingual immunotherapy in allergic patients who underwent this treatment for at least 3 years. Material and methods: We enrolled 76 patients (16 males and 60 females, mean age 34 years old) with evidence of a natural rubber latex allergy. To assess the effectiveness of the immunotherapy we performed a latex skin prick test, specific IgE and IgG4 and challenge tests before and after at least 3 years of desensitization. Results: We observed a reduction in the mean diameter of the wheal area at the skin prick test and a decrease in latex specific IgE while no significant changes of latex IgG4 values were found. Moreover a reduction of symptoms and scores at the provocation tests were remarked. Conclusions: Although the primary prevention (which still remains the gold standard treatment for patients suffering from the latex allergy) sublingual immunotherapy can be offered with efficacy in addition to symptomatic treatment to selected patients.",
keywords = "Challenge, Desensitization, Latex allergy, Sublingual immunotherapy",
author = "Eleonora Nucera and Simona Mezzacappa and Alessandro Buonomo and Michele Centrone and Angela Rizzi and Manicone, {Paolo Francesco} and Giampiero Patriarca and Arianna Aruanno and Domenico Schiavino",
year = "2018",
month = "4",
day = "1",
doi = "10.5114/ada.2018.75235",
language = "English",
volume = "35",
pages = "145--150",
journal = "Postepy Dermatologii I Alergologii",
issn = "1642-395X",
publisher = "Termedia Publishing House Ltd.",
number = "2",

}

TY - JOUR

T1 - Latex immunotherapy

T2 - Evidence of effectiveness

AU - Nucera, Eleonora

AU - Mezzacappa, Simona

AU - Buonomo, Alessandro

AU - Centrone, Michele

AU - Rizzi, Angela

AU - Manicone, Paolo Francesco

AU - Patriarca, Giampiero

AU - Aruanno, Arianna

AU - Schiavino, Domenico

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Introduction: The only etiological and decisive therapy, able to influence the natural history of latex allergy is the specific desensitization. Aim: To verify the clinical efficacy and immunological changes determined by latex sublingual immunotherapy in allergic patients who underwent this treatment for at least 3 years. Material and methods: We enrolled 76 patients (16 males and 60 females, mean age 34 years old) with evidence of a natural rubber latex allergy. To assess the effectiveness of the immunotherapy we performed a latex skin prick test, specific IgE and IgG4 and challenge tests before and after at least 3 years of desensitization. Results: We observed a reduction in the mean diameter of the wheal area at the skin prick test and a decrease in latex specific IgE while no significant changes of latex IgG4 values were found. Moreover a reduction of symptoms and scores at the provocation tests were remarked. Conclusions: Although the primary prevention (which still remains the gold standard treatment for patients suffering from the latex allergy) sublingual immunotherapy can be offered with efficacy in addition to symptomatic treatment to selected patients.

AB - Introduction: The only etiological and decisive therapy, able to influence the natural history of latex allergy is the specific desensitization. Aim: To verify the clinical efficacy and immunological changes determined by latex sublingual immunotherapy in allergic patients who underwent this treatment for at least 3 years. Material and methods: We enrolled 76 patients (16 males and 60 females, mean age 34 years old) with evidence of a natural rubber latex allergy. To assess the effectiveness of the immunotherapy we performed a latex skin prick test, specific IgE and IgG4 and challenge tests before and after at least 3 years of desensitization. Results: We observed a reduction in the mean diameter of the wheal area at the skin prick test and a decrease in latex specific IgE while no significant changes of latex IgG4 values were found. Moreover a reduction of symptoms and scores at the provocation tests were remarked. Conclusions: Although the primary prevention (which still remains the gold standard treatment for patients suffering from the latex allergy) sublingual immunotherapy can be offered with efficacy in addition to symptomatic treatment to selected patients.

KW - Challenge

KW - Desensitization

KW - Latex allergy

KW - Sublingual immunotherapy

UR - http://www.scopus.com/inward/record.url?scp=85046678246&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85046678246&partnerID=8YFLogxK

U2 - 10.5114/ada.2018.75235

DO - 10.5114/ada.2018.75235

M3 - Article

AN - SCOPUS:85046678246

VL - 35

SP - 145

EP - 150

JO - Postepy Dermatologii I Alergologii

JF - Postepy Dermatologii I Alergologii

SN - 1642-395X

IS - 2

ER -