Laugier-Hunziker syndrome with familial distribution

Cataldo Patruno, Francesco Balato, Fabrizio Ayala, Nicola Balato

Research output: Contribution to journalArticle

Abstract

Laugier-Hunziker syndrome (LHS) is an acquired melanosis of lips and/or oral mucosa, in half the cases associated with melanonychia striata and, rarely, with hyperpigmentation of other mucocutaneous districts. LHS with familial distribution has rarely been reported in the literature; notwithstanding, at present it is considered a not uncommon condition. Histology is characterized by increased melanization of the lower layers of epidermis with no expansion of the melanocyte population. 3 relatives (mother and 2 daughters) with LHS of the oral cavity are reported. Differential diagnosis with other causes of oral pigmentation is discussed. Due to the familial distribution, Peutz-Jeghers syndrome must be differentiated for the absence of systemic disturbances and the normal number of melanocytes in the pigmented macules.

Original languageEnglish
Pages (from-to)61-63
Number of pages3
JournalAnnali Italiani di Dermatologia Clinica e Sperimentale
Volume53
Issue number2
Publication statusPublished - May 1999

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Melanocytes
Peutz-Jeghers Syndrome
Melanosis
Hyperpigmentation
Pigmentation
Mouth Mucosa
Lip
Epidermis
Mouth
Histology
Differential Diagnosis
Population

Keywords

  • Hyperpigmentation
  • Labial melanotic macule
  • Laugier-Hunziker syndrome
  • Melanosis

ASJC Scopus subject areas

  • Dermatology

Cite this

Laugier-Hunziker syndrome with familial distribution. / Patruno, Cataldo; Balato, Francesco; Ayala, Fabrizio; Balato, Nicola.

In: Annali Italiani di Dermatologia Clinica e Sperimentale, Vol. 53, No. 2, 05.1999, p. 61-63.

Research output: Contribution to journalArticle

Patruno, Cataldo ; Balato, Francesco ; Ayala, Fabrizio ; Balato, Nicola. / Laugier-Hunziker syndrome with familial distribution. In: Annali Italiani di Dermatologia Clinica e Sperimentale. 1999 ; Vol. 53, No. 2. pp. 61-63.
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