LAV/HTLV-III neutralizing antibodies in the sera of patients with AIDS, lymphadenopathy syndrome and asymptomatic seropositive individuals.

G. P. Faulkner-Valle, A. De Rossi, O. Dalla Gassa, L. Chieco-Bianchi

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Abstract

Serum samples which had previously been found positive for LAV/HTLV-III antibodies by the ELISA test and then confirmed by radioimmunoassay (Western blot) were tested for the presence of neutralizing antibodies. No neutralizing activity was found in the sera of a group of patients with the clinical diagnosis of AIDS. However in patients with LAS and other related pathologic conditions the percentage of sera positive for neutralizing antibodies was 27% and 55% respectively. At least 50% of the sera from seropositive asymptomatic individuals had neutralizing activity but with the exception of the haemophiliac group the mean titre was much lower than that of LAS patients. No relationship was found between the neutralizing titre and the antibody specificity detected by Western blot analysis for p41 and p120.

Original languageEnglish
Pages (from-to)219-224
Number of pages6
JournalTumori
Volume72
Issue number3
Publication statusPublished - Jun 30 1986

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AIDS-Related Complex
HIV Antibodies
Neutralizing Antibodies
Acquired Immunodeficiency Syndrome
HIV
Serum
Western Blotting
Antibody Specificity
Radioimmunoassay
Enzyme-Linked Immunosorbent Assay

ASJC Scopus subject areas

  • Cancer Research

Cite this

LAV/HTLV-III neutralizing antibodies in the sera of patients with AIDS, lymphadenopathy syndrome and asymptomatic seropositive individuals. / Faulkner-Valle, G. P.; De Rossi, A.; Dalla Gassa, O.; Chieco-Bianchi, L.

In: Tumori, Vol. 72, No. 3, 30.06.1986, p. 219-224.

Research output: Contribution to journalArticle

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