LDOC-1 and PARP-1 mRNA expression in leukocytes of father and son with cutaneous malignant melanoma

Michele Salemi, Pier Franco Soma, Rosita A. Condorelli, Domenico Recupero, Aldo E. Calogero

Research output: Contribution to journalArticle

Abstract

Apoptosis is central to the biology of cutaneous malignant melanoma (CMM). The leucine zipper, down regulated in cancer 1 (LDOC-1) gene, is known to be a regulator of the nuclear factor kappa B (NF-kB) through inhibition of the same NF-kB. The poly (ADP-ribose) polymerase-1 (PARP1) gene plays an important role for the efficient maintenance of genome integrity. PARP-1 protein is required for the apoptosis-inducing factor (AIF) translocation from the mitochondria to the nucleus. We report here two interesting cases of family melanoma, a father and son 84 and 40 years old, respectively. The histological evaluation of the lesions of both men revealed diffused superficial melanoma with epithelioid cells. We evaluated the differential expression of LDOC-1 and PARP-1 mRNA in peripheral blood leukocytes of both the father and son. We found that both LDOC-1 and PARP-1 genes were down-regulated in both patients compared with those of controls. These data suggest that low levels of expression of LDOC-1 and PARP-1 mRNA may be associated with familial melanoma.

Original languageEnglish
Pages (from-to)204-207
Number of pages4
JournalCentral European Journal of Medicine
Volume8
Issue number2
DOIs
Publication statusPublished - Apr 2013

Keywords

  • Apoptosis
  • Cutaneous malignant melanoma
  • LDOC-1gene
  • PARP-1 gene
  • qRT-PCR

ASJC Scopus subject areas

  • Medicine(all)

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