Bacterial nonspecific acid phosphohydrolases (NSAPs) are monomeric or oligomeric proteins containing polypeptide components with an Mr of 25 - 30 kDa, able to dephosphorylate a broad array of structurally unrelated substrates and exhibiting optimal catalytic activity at acidic to neutral pH values; they are usually secreted as soluble periplasmic proteins or membrane-bound lipoproteins. On the basis of amino acid sequence relatedness, three different molecular families of NSAPs can be distinguished, indicated as molecular class A, B and C, respectively. Members of each class share some common biophysical and functional features, but may also exhibit functional differences among each other. NSAPs have been detected in several microbial taxa, and enzymes of different classes can be produced by the same bacterial species. Structural and phyletic relationships exist among the various bacterial NSAPs and some other bacterial and eucaryotic phosphohydrolases. An overview is presented, concerning current knowledge on bacterial NSAPs.
|Number of pages||20|
|Issue number||SUPPL. 1|
|Publication status||Published - Jul 1999|
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health