Leanness as early marker of cancer of the oral cavity and pharynx

S. Franceschi, L. D. Maso, F. Levi, E. Conti, R. Talamini, C. L. Vecchia

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Background: It is not clear whether the purported association of leanness with cancer of the oral cavity and pharynx was due to cancer-related weight loss or to the influence of factors associated with leanness. Patients and methods: Seven hundred fifty-four incident cases of cancers of the oral cavity and pharynx and 1775 controls, admitted to hospital for acute, non-neoplastic diseases, in Italy and Switzerland. Questionnaire included height, lifetime history of weight and of physical activity, waist and hip measurements, and a validated food-frequency section. Results: Leanness at diagnosis was associated with elevated risk in men (adjusted odds ratio, OR for 5-unit decrease in body-mass index, BMI = 1.9; 95% confidence interval (CI): 1.6-2.2 in men). Male cases were significantly leaner than control subjects at the age of 30 and of 50. Thinner women also had an increased risk, but the inverse association with BMI was non linear. In both sexes, the association with leanness was restricted to smokers and moderate/heavy drinkers, but was not accounted for by drinking and smoking habits, nor by differences in physical activity or dietary habits. Conclusions: Leanness appears to be an early marker of some unknown biological effect of smoking and/or of alcohol abuse, which may contribute to the prediction of cancers of the oral cavity and pharynx. Cessation of smoking and substantial reduction of alcohol intake may improve nutritional status, besides stopping carcinogen exposure.

Original languageEnglish
Pages (from-to)331-336
Number of pages6
JournalAnnals of Oncology
Volume12
Issue number3
DOIs
Publication statusPublished - 2001

Fingerprint

Pharyngeal Neoplasms
Thinness
Mouth Neoplasms
Mouth
Smoking
Exercise
Feeding Behavior
Smoking Cessation
Nutritional Status
Switzerland
Carcinogens
Italy
Alcoholism
Drinking
Habits
Hip
Weight Loss
Body Mass Index
Odds Ratio
Alcohols

Keywords

  • Body mass index
  • Drinking
  • Oral cancer
  • Pharyngeal cancer
  • Smoking

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Franceschi, S., Maso, L. D., Levi, F., Conti, E., Talamini, R., & Vecchia, C. L. (2001). Leanness as early marker of cancer of the oral cavity and pharynx. Annals of Oncology, 12(3), 331-336. https://doi.org/10.1023/A:1011191809335

Leanness as early marker of cancer of the oral cavity and pharynx. / Franceschi, S.; Maso, L. D.; Levi, F.; Conti, E.; Talamini, R.; Vecchia, C. L.

In: Annals of Oncology, Vol. 12, No. 3, 2001, p. 331-336.

Research output: Contribution to journalArticle

Franceschi, S, Maso, LD, Levi, F, Conti, E, Talamini, R & Vecchia, CL 2001, 'Leanness as early marker of cancer of the oral cavity and pharynx', Annals of Oncology, vol. 12, no. 3, pp. 331-336. https://doi.org/10.1023/A:1011191809335
Franceschi, S. ; Maso, L. D. ; Levi, F. ; Conti, E. ; Talamini, R. ; Vecchia, C. L. / Leanness as early marker of cancer of the oral cavity and pharynx. In: Annals of Oncology. 2001 ; Vol. 12, No. 3. pp. 331-336.
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