Learning potentiates neurophysiological and behavioral placebo analgesic responses

Luana Colloca, Michele Tinazzi, Serena Recchia, Domenica Le Pera, Antonio Fiaschi, Fabrizio Benedetti, Massimiliano Valeriani

Research output: Contribution to journalArticle

Abstract

Expectation and conditioning are supposed to be the two main psychological mechanisms for inducing a placebo response. Here, we further investigate the effects of both expectation, which was induced by verbal suggestion alone, and conditioning at the level of N1 and N2-P2 components of CO2 laser-evoked potentials (LEPs) and subjective pain reports. Forty-four healthy volunteers were pseudorandomly assigned to one of three experimental groups: Group 1 was tested with verbal suggestion alone, Group 2 was tested with a conditioning procedure, whereby the intensity of painful stimulation was reduced surreptitiously, so as to make the volunteers believe that the treatment was effective, Group 3 was a control group that allowed us to rule out phenomena of sensitization and/or habituation. Pain perception was assessed according to a Numerical Rating Scale (NRS) ranging from 0 = no pain sensation to 10 = maximum imaginable pain. Both verbal suggestions (Group 1) and conditioning (Group 2) modified the N2-P2 complex, but not the N1 component of LEPs. However, the suggestion-induced LEP changes occurred without subjective perception of pain decrease. Conversely, the N2-P2 amplitude changes that were induced by the conditioning procedure were associated with the subjective perception of pain reduction. Compared to natural history, conditioning produced more robust reductions of LEP amplitudes than verbal suggestions alone. Overall, these findings indicate that prior positive experience plays a key role in maximizing both behavioral and neurophysiological placebo responses, emphasizing that the placebo effect is a learning phenomenon which affects the early central nociceptive processing.

Original languageEnglish
Pages (from-to)306-314
Number of pages9
JournalPain
Volume139
Issue number2
DOIs
Publication statusPublished - Oct 15 2008

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Analgesics
Placebos
Learning
Pain Perception
Pain
Placebo Effect
Gas Lasers
Natural History
Conditioning (Psychology)
Volunteers
Healthy Volunteers
Psychology
Control Groups
Laser-Evoked Potentials

Keywords

  • Conditioning
  • Expectation
  • Laser-evoked potentials
  • Learning
  • Placebo analgesia

ASJC Scopus subject areas

  • Clinical Neurology
  • Anesthesiology and Pain Medicine
  • Neurology
  • Pharmacology

Cite this

Learning potentiates neurophysiological and behavioral placebo analgesic responses. / Colloca, Luana; Tinazzi, Michele; Recchia, Serena; Le Pera, Domenica; Fiaschi, Antonio; Benedetti, Fabrizio; Valeriani, Massimiliano.

In: Pain, Vol. 139, No. 2, 15.10.2008, p. 306-314.

Research output: Contribution to journalArticle

Colloca L, Tinazzi M, Recchia S, Le Pera D, Fiaschi A, Benedetti F et al. Learning potentiates neurophysiological and behavioral placebo analgesic responses. Pain. 2008 Oct 15;139(2):306-314. https://doi.org/10.1016/j.pain.2008.04.021
Colloca, Luana ; Tinazzi, Michele ; Recchia, Serena ; Le Pera, Domenica ; Fiaschi, Antonio ; Benedetti, Fabrizio ; Valeriani, Massimiliano. / Learning potentiates neurophysiological and behavioral placebo analgesic responses. In: Pain. 2008 ; Vol. 139, No. 2. pp. 306-314.
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