Learning processes and brain connectivity in a cognitive-motor task in neurodegeneration: Evidence from EEG network analysis

F. Vecchio, F. Miraglia, D. Quaranta, G. Lacidogna, C. Marra, P.M. Rossini

Research output: Contribution to journalArticle

Abstract

Electroencephalographic (EEG) rhythms are linked to any kind of learning and cognitive performance including motor tasks. The brain is a complex network consisting of spatially distributed networks dedicated to different functions including cognitive domains where dynamic interactions of several brain areas play a pivotal role. Brain connectome could be a useful approach not only to mechanisms underlying brain cognitive functions, but also to those supporting different mental states. This goal was approached via a learning task providing the possibility to predict performance and learning along physiological and pathological brain aging. Eighty-six subjects (22 healthy, 47 amnesic mild cognitive impairment, 17 Alzheimer's disease) were recruited reflecting the whole spectrum of normal and abnormal brain connectivity scenarios. EEG recordings were performed at rest, with closed eyes, both before and after the task (Sensory Motor Learning task consisting of a visual rotation paradigm). Brain network properties were described by Small World index (SW), representing a combination of segregation and integration properties. Correlation analyses showed that alpha 2 SW in pre-task significantly predict learning (r = -0.2592, p
Original languageEnglish
Pages (from-to)471-481
Number of pages11
JournalJournal of Alzheimer's Disease
Volume66
Issue number2
DOIs
Publication statusPublished - 2018

Keywords

  • activity of daily living assessment
  • aged
  • Alzheimer disease
  • Article
  • Clinical Dementia Rating
  • cognition
  • connectome
  • controlled study
  • correlation analysis
  • degenerative disease
  • electroencephalogram
  • functional connectivity
  • Geriatric Depression Scale
  • human
  • learning
  • major clinical study
  • mental health
  • mild cognitive impairment
  • Mini Mental State Examination
  • motor learning
  • neurologic disease
  • nuclear magnetic resonance imaging
  • patient monitoring
  • priority journal
  • single photon emission computed tomography
  • task performance

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