Leber's congenital amaurosis: Is there an autistic component?

E. Fazzi, M. Rossi, S. Signorini, G. Rossi, P. E. Bianchi, G. Lanzi

Research output: Contribution to journalArticlepeer-review


There is much evidence in the literature suggesting that children with congenital blindness can also present autistic like features. The aetiopathogenetic and clinical significance of this association is still unclear. Given the central role played by vision in development, we set out to establish the significance of autistic-like behaviours in children with early-onset severe visual impairment. Our sample comprised 24 children (13 males, 11 females; mean age 5y 2mo; range 2-11y) affected by Leber's congenital amaurosis (LCA). The results of our administration of a modified Childhood Austism Rating Scale - excluding item VII (Visual Responsiveness) - showed that only four of the children gave an overall score indicating the presence of autism (moreover, of mild/moderate degree). Hardly any of the children in our LCA sample presented major dysfunctions in their relationships with other people or in their social and emotional responsiveness, thus allowing us to exclude a genuine comorbidity with a picture of autism. Indeed, the risk facing the visually impaired child seems to concern their early interactive experiences, which may be affected by their inability to connect with others, and may be prevented through the development of specific strategies of intervention.

Original languageEnglish
Pages (from-to)503-507
Number of pages5
JournalDevelopmental Medicine and Child Neurology
Issue number7
Publication statusPublished - Jul 2007

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neuroscience(all)


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