Lectin-like, oxidized low-density lipoprotein receptor-1 (LOX-1): A critical player in the development of atherosclerosis and related disorders

Jawahar L. Mehta, Jiawei Chen, Paul L. Hermonat, Francesco Romeo, Giuseppe Novelli

Research output: Contribution to journalArticlepeer-review

Abstract

LOX-1, a lectin-like 52-kD receptor for oxidized low-density lipoproteins (ox-LDL), is present primarily on endothelial cells. This receptor is upregulated by ox-LDL itself and by angiotensin II, endothelin, cytokines, and shear stress, all participants in atherosclerosis. This receptor is upregulated in the arteries of hypertensive, dyslipidemic, and diabetic animals. Upregulation of LOX-1 has been identified in atherosclerotic arteries of several animal species and humans, not only on the endothelial lining, but also in the neovasculature of the atherosclerotic plaque, and this receptor is often co-localized with apoptotic cells. Recent studies show upregulation of LOX-1 in the ischemic-reperfused myocardium. LOX-1 inhibition is associated with attenuation of atherosclerosis and associated ischemic injury. LOX-1 may be a novel, exciting target for drug therapy.

Original languageEnglish
Pages (from-to)36-45
Number of pages10
JournalCardiovascular Research
Volume69
Issue number1
DOIs
Publication statusPublished - Jan 2006

Keywords

  • Lipids receptors
  • LOX-1
  • Oxidised LDL

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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