Leech antihemostatic proteins share the T-knot scaffold, a disulfide-reinforced structural motif

Paolo Ascenzi, Martino Bolognesi, Daniele Catalucci, Stefano Pascarella, Margherita Ruoppolo, Menico Rizzi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The occcurence of similar topologies among unrelated proteins is an emerging theme in structural biology. Here we report that the T-knot scaffold, a disulfide-reinforced structural motif shared by knottins and EGF-like proteins, is also present in leech antihemostatic proteins. Our finding emphasizes the versatile nature of this small structural motif, representing a compact structural unit suitable for the diverse biological functions performed by knottins, EGF-like proteins and leech antihemostatic proteins.

Original languageEnglish
Pages (from-to)1387-1389
Number of pages3
JournalBiological Chemistry
Volume379
Issue number11
Publication statusPublished - 1998

Fingerprint

Leeches
Scaffolds
Disulfides
Cystine-Knot Miniproteins
Proteins
Epidermal Growth Factor
Topology

Keywords

  • Antistasin
  • Decorsin
  • EGF-like proteins
  • Hirudin
  • Knottins
  • T-knot scaffold

ASJC Scopus subject areas

  • Biochemistry

Cite this

Ascenzi, P., Bolognesi, M., Catalucci, D., Pascarella, S., Ruoppolo, M., & Rizzi, M. (1998). Leech antihemostatic proteins share the T-knot scaffold, a disulfide-reinforced structural motif. Biological Chemistry, 379(11), 1387-1389.

Leech antihemostatic proteins share the T-knot scaffold, a disulfide-reinforced structural motif. / Ascenzi, Paolo; Bolognesi, Martino; Catalucci, Daniele; Pascarella, Stefano; Ruoppolo, Margherita; Rizzi, Menico.

In: Biological Chemistry, Vol. 379, No. 11, 1998, p. 1387-1389.

Research output: Contribution to journalArticle

Ascenzi, P, Bolognesi, M, Catalucci, D, Pascarella, S, Ruoppolo, M & Rizzi, M 1998, 'Leech antihemostatic proteins share the T-knot scaffold, a disulfide-reinforced structural motif', Biological Chemistry, vol. 379, no. 11, pp. 1387-1389.
Ascenzi P, Bolognesi M, Catalucci D, Pascarella S, Ruoppolo M, Rizzi M. Leech antihemostatic proteins share the T-knot scaffold, a disulfide-reinforced structural motif. Biological Chemistry. 1998;379(11):1387-1389.
Ascenzi, Paolo ; Bolognesi, Martino ; Catalucci, Daniele ; Pascarella, Stefano ; Ruoppolo, Margherita ; Rizzi, Menico. / Leech antihemostatic proteins share the T-knot scaffold, a disulfide-reinforced structural motif. In: Biological Chemistry. 1998 ; Vol. 379, No. 11. pp. 1387-1389.
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