Abstract
The occcurence of similar topologies among unrelated proteins is an emerging theme in structural biology. Here we report that the T-knot scaffold, a disulfide-reinforced structural motif shared by knottins and EGF-like proteins, is also present in leech antihemostatic proteins. Our finding emphasizes the versatile nature of this small structural motif, representing a compact structural unit suitable for the diverse biological functions performed by knottins, EGF-like proteins and leech antihemostatic proteins.
Original language | English |
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Pages (from-to) | 1387-1389 |
Number of pages | 3 |
Journal | Biological Chemistry |
Volume | 379 |
Issue number | 11 |
Publication status | Published - 1998 |
Keywords
- Antistasin
- Decorsin
- EGF-like proteins
- Hirudin
- Knottins
- T-knot scaffold
ASJC Scopus subject areas
- Biochemistry