Left atrial strain and strain rate before and following restrictive annuloplasty for ischaemic mitral regurgitation evaluated by two-dimensional speckle tracking echocardiography

Leen Van Garsse, Sandro Gelsomino, Fabiana Lucà, Orlando Parise, Emile Cheriex, Carmelo Massimiliano Rao, Gian Franco Gensini, Jos G. Maessen

Research output: Contribution to journalArticle

Abstract

AimsWe retrospectively evaluated left atrial (LA) strain and strain rate (SR) before and after undersized mitral ring annuloplasty (UMRA) for chronic ischaemic mitral regurgitation (CIMR) with two-dimensional speckle-tracking echocardiography.Methods and resultsLeft atrial volumes, LA reservoir, LA conduit, LA contractile phases, and LA ejection fraction (LAEF) were measured in 95 CIMR patients who underwent coronary bypass grafting and UMRA. Left atrial peak global strain (ε), LA reservoir (SRp), LA conduit (SR E), and LA contractile phase (SRA) strain rates were obtained at the baseline and at the follow-up (median 41.5 months, interquartile range 23-61). Based on the recurrence of mitral regurgitation (MR) at the follow-up, the patients were divided into two groups: patients with (group MR+, n = 30) or without (group MR-, n = 65) recurrent MR. Twenty age-and gender-matched healthy adults were controls. In the MR-group, baseline ε (P <0.001), SRP (P <0.001), SRE (P <0.001), and SRA (P <0.001) were enhanced, while in MR+ group, ε (P <0.001), SRP (P = 0.03), SRE (P = 0.03), and SRA (P = 0.003) were worse than controls. At the follow-up, none of these indices changed in the MR+ group while all returned to normal values in patients belonging to the MR-group. Left atrial deformation correlated with corresponding volumetric parameters. Furthermore, we found a direct correlation between SRE and early peak diastolic velocity (E) (ρ = 0.52, P = 0.02) and E-wave deceleration time (ρ = 0.50, P = 0.02). Finally, there was a strong correlation between ε, SRP, and SRA (ρ = 0.72, P <0.001 and ρ = 0.79, P <0.001, respectively) and SR E (ρ = 0.69, P <0.001 and ρ = 0.71, P <0.001, respectively). Finally, ε, SRP, and SRE (all, P <0.001) were co-factors associated to recurrent MR.ConclusionLeft atrial peak global strain, peak systolic SR, and peak early diastolic SR were cofactors associated to recurrent MR. The assessment of LA strain and SR, in addition to other echocardiographic parameters, can be helpful in detecting patients undergoing UMRA who are unlikely to benefit from annuloplasty. Published on behalf of the European Society of Cardiology. All rights reserved.

Original languageEnglish
Pages (from-to)534-543
Number of pages10
JournalEuropean Heart Journal Cardiovascular Imaging
Volume14
Issue number6
DOIs
Publication statusPublished - Jun 2013

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Mitral Valve Insufficiency
Echocardiography
Mitral Valve Annuloplasty
Deceleration
Reference Values

Keywords

  • Echocardiography
  • Mitral valve
  • Myocardial infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Left atrial strain and strain rate before and following restrictive annuloplasty for ischaemic mitral regurgitation evaluated by two-dimensional speckle tracking echocardiography. / Van Garsse, Leen; Gelsomino, Sandro; Lucà, Fabiana; Parise, Orlando; Cheriex, Emile; Rao, Carmelo Massimiliano; Gensini, Gian Franco; Maessen, Jos G.

In: European Heart Journal Cardiovascular Imaging, Vol. 14, No. 6, 06.2013, p. 534-543.

Research output: Contribution to journalArticle

Van Garsse, Leen ; Gelsomino, Sandro ; Lucà, Fabiana ; Parise, Orlando ; Cheriex, Emile ; Rao, Carmelo Massimiliano ; Gensini, Gian Franco ; Maessen, Jos G. / Left atrial strain and strain rate before and following restrictive annuloplasty for ischaemic mitral regurgitation evaluated by two-dimensional speckle tracking echocardiography. In: European Heart Journal Cardiovascular Imaging. 2013 ; Vol. 14, No. 6. pp. 534-543.
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title = "Left atrial strain and strain rate before and following restrictive annuloplasty for ischaemic mitral regurgitation evaluated by two-dimensional speckle tracking echocardiography",
abstract = "AimsWe retrospectively evaluated left atrial (LA) strain and strain rate (SR) before and after undersized mitral ring annuloplasty (UMRA) for chronic ischaemic mitral regurgitation (CIMR) with two-dimensional speckle-tracking echocardiography.Methods and resultsLeft atrial volumes, LA reservoir, LA conduit, LA contractile phases, and LA ejection fraction (LAEF) were measured in 95 CIMR patients who underwent coronary bypass grafting and UMRA. Left atrial peak global strain (ε), LA reservoir (SRp), LA conduit (SR E), and LA contractile phase (SRA) strain rates were obtained at the baseline and at the follow-up (median 41.5 months, interquartile range 23-61). Based on the recurrence of mitral regurgitation (MR) at the follow-up, the patients were divided into two groups: patients with (group MR+, n = 30) or without (group MR-, n = 65) recurrent MR. Twenty age-and gender-matched healthy adults were controls. In the MR-group, baseline ε (P <0.001), SRP (P <0.001), SRE (P <0.001), and SRA (P <0.001) were enhanced, while in MR+ group, ε (P <0.001), SRP (P = 0.03), SRE (P = 0.03), and SRA (P = 0.003) were worse than controls. At the follow-up, none of these indices changed in the MR+ group while all returned to normal values in patients belonging to the MR-group. Left atrial deformation correlated with corresponding volumetric parameters. Furthermore, we found a direct correlation between SRE and early peak diastolic velocity (E) (ρ = 0.52, P = 0.02) and E-wave deceleration time (ρ = 0.50, P = 0.02). Finally, there was a strong correlation between ε, SRP, and SRA (ρ = 0.72, P <0.001 and ρ = 0.79, P <0.001, respectively) and SR E (ρ = 0.69, P <0.001 and ρ = 0.71, P <0.001, respectively). Finally, ε, SRP, and SRE (all, P <0.001) were co-factors associated to recurrent MR.ConclusionLeft atrial peak global strain, peak systolic SR, and peak early diastolic SR were cofactors associated to recurrent MR. The assessment of LA strain and SR, in addition to other echocardiographic parameters, can be helpful in detecting patients undergoing UMRA who are unlikely to benefit from annuloplasty. Published on behalf of the European Society of Cardiology. All rights reserved.",
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T1 - Left atrial strain and strain rate before and following restrictive annuloplasty for ischaemic mitral regurgitation evaluated by two-dimensional speckle tracking echocardiography

AU - Van Garsse, Leen

AU - Gelsomino, Sandro

AU - Lucà, Fabiana

AU - Parise, Orlando

AU - Cheriex, Emile

AU - Rao, Carmelo Massimiliano

AU - Gensini, Gian Franco

AU - Maessen, Jos G.

PY - 2013/6

Y1 - 2013/6

N2 - AimsWe retrospectively evaluated left atrial (LA) strain and strain rate (SR) before and after undersized mitral ring annuloplasty (UMRA) for chronic ischaemic mitral regurgitation (CIMR) with two-dimensional speckle-tracking echocardiography.Methods and resultsLeft atrial volumes, LA reservoir, LA conduit, LA contractile phases, and LA ejection fraction (LAEF) were measured in 95 CIMR patients who underwent coronary bypass grafting and UMRA. Left atrial peak global strain (ε), LA reservoir (SRp), LA conduit (SR E), and LA contractile phase (SRA) strain rates were obtained at the baseline and at the follow-up (median 41.5 months, interquartile range 23-61). Based on the recurrence of mitral regurgitation (MR) at the follow-up, the patients were divided into two groups: patients with (group MR+, n = 30) or without (group MR-, n = 65) recurrent MR. Twenty age-and gender-matched healthy adults were controls. In the MR-group, baseline ε (P <0.001), SRP (P <0.001), SRE (P <0.001), and SRA (P <0.001) were enhanced, while in MR+ group, ε (P <0.001), SRP (P = 0.03), SRE (P = 0.03), and SRA (P = 0.003) were worse than controls. At the follow-up, none of these indices changed in the MR+ group while all returned to normal values in patients belonging to the MR-group. Left atrial deformation correlated with corresponding volumetric parameters. Furthermore, we found a direct correlation between SRE and early peak diastolic velocity (E) (ρ = 0.52, P = 0.02) and E-wave deceleration time (ρ = 0.50, P = 0.02). Finally, there was a strong correlation between ε, SRP, and SRA (ρ = 0.72, P <0.001 and ρ = 0.79, P <0.001, respectively) and SR E (ρ = 0.69, P <0.001 and ρ = 0.71, P <0.001, respectively). Finally, ε, SRP, and SRE (all, P <0.001) were co-factors associated to recurrent MR.ConclusionLeft atrial peak global strain, peak systolic SR, and peak early diastolic SR were cofactors associated to recurrent MR. The assessment of LA strain and SR, in addition to other echocardiographic parameters, can be helpful in detecting patients undergoing UMRA who are unlikely to benefit from annuloplasty. Published on behalf of the European Society of Cardiology. All rights reserved.

AB - AimsWe retrospectively evaluated left atrial (LA) strain and strain rate (SR) before and after undersized mitral ring annuloplasty (UMRA) for chronic ischaemic mitral regurgitation (CIMR) with two-dimensional speckle-tracking echocardiography.Methods and resultsLeft atrial volumes, LA reservoir, LA conduit, LA contractile phases, and LA ejection fraction (LAEF) were measured in 95 CIMR patients who underwent coronary bypass grafting and UMRA. Left atrial peak global strain (ε), LA reservoir (SRp), LA conduit (SR E), and LA contractile phase (SRA) strain rates were obtained at the baseline and at the follow-up (median 41.5 months, interquartile range 23-61). Based on the recurrence of mitral regurgitation (MR) at the follow-up, the patients were divided into two groups: patients with (group MR+, n = 30) or without (group MR-, n = 65) recurrent MR. Twenty age-and gender-matched healthy adults were controls. In the MR-group, baseline ε (P <0.001), SRP (P <0.001), SRE (P <0.001), and SRA (P <0.001) were enhanced, while in MR+ group, ε (P <0.001), SRP (P = 0.03), SRE (P = 0.03), and SRA (P = 0.003) were worse than controls. At the follow-up, none of these indices changed in the MR+ group while all returned to normal values in patients belonging to the MR-group. Left atrial deformation correlated with corresponding volumetric parameters. Furthermore, we found a direct correlation between SRE and early peak diastolic velocity (E) (ρ = 0.52, P = 0.02) and E-wave deceleration time (ρ = 0.50, P = 0.02). Finally, there was a strong correlation between ε, SRP, and SRA (ρ = 0.72, P <0.001 and ρ = 0.79, P <0.001, respectively) and SR E (ρ = 0.69, P <0.001 and ρ = 0.71, P <0.001, respectively). Finally, ε, SRP, and SRE (all, P <0.001) were co-factors associated to recurrent MR.ConclusionLeft atrial peak global strain, peak systolic SR, and peak early diastolic SR were cofactors associated to recurrent MR. The assessment of LA strain and SR, in addition to other echocardiographic parameters, can be helpful in detecting patients undergoing UMRA who are unlikely to benefit from annuloplasty. Published on behalf of the European Society of Cardiology. All rights reserved.

KW - Echocardiography

KW - Mitral valve

KW - Myocardial infarction

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