Left bundle-branch block - Pathophysiology, prognosis, and clinical management

Pietro Francia, Cristina Balla, Francesco Paneni, Massimo Volpe

Research output: Contribution to journalArticlepeer-review


Given its broad use as a screening tool, the electrocardiogram (ECG) has largely become one of the most common diagnostic tests performed in routine clinical practice. As a result, the finding of left bundle-branch block (LBBB) in the absence of a well-defined clinical setting has become relatively frequent and raises questions and often concerns. While in the absence of clinically detectable heart disease LBBB does not necessarily imply poor outcomes, physicians should be aware of the role of LBBB in stratifying risk of cardiovascular events and death in subjects with both ischemic and nonischemic heart disease. This paper reviews historical landmarks, pathophysiologic features, prognostic implications, and clinical management of LBBB in apparently healthy subjects and those with heart disease.

Original languageEnglish
Pages (from-to)110-115
Number of pages6
JournalClinical Cardiology
Issue number3
Publication statusPublished - Mar 2007


  • Electrocardiogram
  • History of medicine
  • Left bundle-branch block

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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