Left cardiac sympathetic denervation for catecholaminergic polymorphic ventricular tachycardia

Arthur A M Wilde, Zahurul A. Bhuiyan, Lia Crotti, Mario Facchini, Gaetano M. De Ferrari, Thomas Paul, Chiara Ferrandi, Dave R. Koolbergen, Attilio Odero, Peter J. Schwartz

Research output: Contribution to journalArticlepeer-review

Abstract

Catecholaminergic polymorphic ventricular tachycardia is a potentially lethal disease characterized by adrenergically mediated ventricular arrhythmias manifested especially in children and teenagers. Beta-blockers are the cornerstone of therapy, but some patients do not have a complete response to this therapy and receive an implantable cardioverter-defibrillator (ICD). Given the nature of catecholaminergic polymorphic ventricular tachycardia, ICD shocks may trigger new arrhythmias, leading to the administration of multiple shocks. We describe the long-term efficacy of surgical left cardiac sympathetic denervation in three young adults with catecholaminergic polymorphic ventricular tachycardia, all of whom had symptoms before the procedure and were symptom-free afterward.

Original languageEnglish
Pages (from-to)2024-2029
Number of pages6
JournalNew England Journal of Medicine
Volume358
Issue number19
DOIs
Publication statusPublished - May 8 2008

ASJC Scopus subject areas

  • Medicine(all)

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