Abstract
Background - The management of long-QT syndrome (LQTS) patients who continue to have cardiac events (CEs) despite β-blockers is complex. We assessed the long-term efficacy of left cardiac sympathetic denervation (LCSD) in a group of high-risk patients. Methods and Results - We identified 147 LQTS patients who underwent LCSD. Their QT interval was very prolonged (QTc, 543±65 ms); 99% were symptomatic; 48% had a cardiac arrest; and 75% of those treated with β-blockers remained symptomatic. The average follow-up periods between first CE and LCSD and post-LCSD were 4.6 and 7.8 years, respectively. After LCSD, 46% remained asymptomatic. Syncope occurred in 31%, aborted cardiac arrest in 16%, and sudden death in 7%. The mean yearly number of CEs per patient dropped by 91% (P5 CEs declined from 55% to 8% (P
Original language | English |
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Pages (from-to) | 1826-1833 |
Number of pages | 8 |
Journal | Circulation |
Volume | 109 |
Issue number | 15 |
DOIs | |
Publication status | Published - Apr 20 2004 |
Keywords
- Death, sudden
- Genetics
- Long-QT syndrome
- Nervous system, sympathetic
ASJC Scopus subject areas
- Physiology
- Cardiology and Cardiovascular Medicine