Left Cardiac Sympathetic Denervation in the Management of High-Risk Patients Affected by the Long-QT Syndrome

Peter J. Schwartz; Silvia G. Priori; Marina Cerrone; Carla Spazzolini; Attilio Odero; Carlo Napolitano; Raffaella Bloise; Gaetano M. De Ferrari; Catherine Klersy; Arthur J. Moss; Wojciech Zareba; Jennifer L. Robinson; W. Jackson Hall; Paul A. Brink; Lauri Toivonen; Andrew E. Epstein; Cuilan Li; Dayi Hu

doi:10.1161/01.CIR.0000125523.14403.1E

Left Cardiac Sympathetic Denervation in the Management of High-Risk Patients Affected by the Long-QT Syndrome

Peter J. Schwartz, Silvia G. Priori, Marina Cerrone, Carla Spazzolini, Attilio Odero, Carlo Napolitano, Raffaella Bloise, Gaetano M. De Ferrari, Catherine Klersy, Arthur J. Moss, Wojciech Zareba, Jennifer L. Robinson, W. Jackson Hall, Paul A. Brink, Lauri Toivonen, Andrew E. Epstein, Cuilan Li, Dayi Hu

Research output: Contribution to journal › Article › peer-review

Abstract

Background - The management of long-QT syndrome (LQTS) patients who continue to have cardiac events (CEs) despite β-blockers is complex. We assessed the long-term efficacy of left cardiac sympathetic denervation (LCSD) in a group of high-risk patients. Methods and Results - We identified 147 LQTS patients who underwent LCSD. Their QT interval was very prolonged (QTc, 543±65 ms); 99% were symptomatic; 48% had a cardiac arrest; and 75% of those treated with β-blockers remained symptomatic. The average follow-up periods between first CE and LCSD and post-LCSD were 4.6 and 7.8 years, respectively. After LCSD, 46% remained asymptomatic. Syncope occurred in 31%, aborted cardiac arrest in 16%, and sudden death in 7%. The mean yearly number of CEs per patient dropped by 91% (P5 CEs declined from 55% to 8% (P

Original language	English
Pages (from-to)	1826-1833
Number of pages	8
Journal	Circulation
Volume	109
Issue number	15
DOIs	https://doi.org/10.1161/01.CIR.0000125523.14403.1E
Publication status	Published - Apr 20 2004

Keywords

Death, sudden
Genetics
Long-QT syndrome
Nervous system, sympathetic

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine

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10.1161/01.CIR.0000125523.14403.1E

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Schwartz, P. J., Priori, S. G., Cerrone, M., Spazzolini, C., Odero, A., Napolitano, C., Bloise, R., De Ferrari, G. M., Klersy, C., Moss, A. J., Zareba, W., Robinson, J. L., Hall, W. J., Brink, P. A., Toivonen, L., Epstein, A. E., Li, C., & Hu, D. (2004). Left Cardiac Sympathetic Denervation in the Management of High-Risk Patients Affected by the Long-QT Syndrome. Circulation, 109(15), 1826-1833. https://doi.org/10.1161/01.CIR.0000125523.14403.1E

Schwartz, PJ , Priori, SG, Cerrone, M, Spazzolini, C, Odero, A, Napolitano, C, Bloise, R , De Ferrari, GM , Klersy, C, Moss, AJ, Zareba, W, Robinson, JL, Hall, WJ, Brink, PA, Toivonen, L, Epstein, AE, Li, C & Hu, D 2004, 'Left Cardiac Sympathetic Denervation in the Management of High-Risk Patients Affected by the Long-QT Syndrome', Circulation, vol. 109, no. 15, pp. 1826-1833. https://doi.org/10.1161/01.CIR.0000125523.14403.1E

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abstract = "Background - The management of long-QT syndrome (LQTS) patients who continue to have cardiac events (CEs) despite β-blockers is complex. We assessed the long-term efficacy of left cardiac sympathetic denervation (LCSD) in a group of high-risk patients. Methods and Results - We identified 147 LQTS patients who underwent LCSD. Their QT interval was very prolonged (QTc, 543±65 ms); 99% were symptomatic; 48% had a cardiac arrest; and 75% of those treated with β-blockers remained symptomatic. The average follow-up periods between first CE and LCSD and post-LCSD were 4.6 and 7.8 years, respectively. After LCSD, 46% remained asymptomatic. Syncope occurred in 31%, aborted cardiac arrest in 16%, and sudden death in 7%. The mean yearly number of CEs per patient dropped by 91% (P5 CEs declined from 55% to 8% (P",

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AU - Priori, Silvia G.

AU - Cerrone, Marina

AU - Spazzolini, Carla

AU - Odero, Attilio

AU - Napolitano, Carlo

AU - Bloise, Raffaella

AU - De Ferrari, Gaetano M.

AU - Klersy, Catherine

AU - Moss, Arthur J.

AU - Zareba, Wojciech

AU - Robinson, Jennifer L.

AU - Hall, W. Jackson

AU - Brink, Paul A.

AU - Toivonen, Lauri

AU - Epstein, Andrew E.

AU - Li, Cuilan

AU - Hu, Dayi

PY - 2004/4/20

Y1 - 2004/4/20

N2 - Background - The management of long-QT syndrome (LQTS) patients who continue to have cardiac events (CEs) despite β-blockers is complex. We assessed the long-term efficacy of left cardiac sympathetic denervation (LCSD) in a group of high-risk patients. Methods and Results - We identified 147 LQTS patients who underwent LCSD. Their QT interval was very prolonged (QTc, 543±65 ms); 99% were symptomatic; 48% had a cardiac arrest; and 75% of those treated with β-blockers remained symptomatic. The average follow-up periods between first CE and LCSD and post-LCSD were 4.6 and 7.8 years, respectively. After LCSD, 46% remained asymptomatic. Syncope occurred in 31%, aborted cardiac arrest in 16%, and sudden death in 7%. The mean yearly number of CEs per patient dropped by 91% (P5 CEs declined from 55% to 8% (P

AB - Background - The management of long-QT syndrome (LQTS) patients who continue to have cardiac events (CEs) despite β-blockers is complex. We assessed the long-term efficacy of left cardiac sympathetic denervation (LCSD) in a group of high-risk patients. Methods and Results - We identified 147 LQTS patients who underwent LCSD. Their QT interval was very prolonged (QTc, 543±65 ms); 99% were symptomatic; 48% had a cardiac arrest; and 75% of those treated with β-blockers remained symptomatic. The average follow-up periods between first CE and LCSD and post-LCSD were 4.6 and 7.8 years, respectively. After LCSD, 46% remained asymptomatic. Syncope occurred in 31%, aborted cardiac arrest in 16%, and sudden death in 7%. The mean yearly number of CEs per patient dropped by 91% (P5 CEs declined from 55% to 8% (P

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Left Cardiac Sympathetic Denervation in the Management of High-Risk Patients Affected by the Long-QT Syndrome

Abstract

Keywords

ASJC Scopus subject areas

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