Left cardiac sympathetic denervation in the therapy of congenital long QT syndrome: A worldwide report

P. J. Schwartz, E. H. Locati, A. J. Moss, R. S. Crampton, R. Trazzi, U. Ruberti

Research output: Contribution to journalArticle

Abstract

Background. Long QT syndrome (LQTS) is a congenital disorder accompanied by a high incidence of sudden cardiac death. β-Adrenergic blockade is the therapy of choice, and it is successful in 75-80% of patients. For those in whom cardiac events (syncope or cardiac arrest) are not prevented by β-blockade, experimental studies suggest that left cardiac sympathetic denervation (LCSD) may be useful. Methods and Results. We identified 85 LQTS patients worldwide who underwent LCSD, and we provide here the first large-scale evaluation of its efficacy. The time interval between the first cardiac event and LCSD and the follow-up period after LCSD were similar (5.6±6.1 versus 5.9±5.7 years). The mean age of the patients at surgery was 20±13 years. LCSD was followed by highly significant (p

Original languageEnglish
Pages (from-to)503-511
Number of pages9
JournalCirculation
Volume84
Issue number2
Publication statusPublished - 1991

Keywords

  • QT interval
  • Sudden cardiac death
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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    Schwartz, P. J., Locati, E. H., Moss, A. J., Crampton, R. S., Trazzi, R., & Ruberti, U. (1991). Left cardiac sympathetic denervation in the therapy of congenital long QT syndrome: A worldwide report. Circulation, 84(2), 503-511.