Left frontal lobe, high-frequency, repetitive transcranial magnetic stimulation in patients affected by depression: A case control pilot study on short-and long-term effect

M. Bortolomasi, P. Manganotti, A. Comencini, S. Patuzzo, A. Palermo, G. M. Giacopuzzi, A. Fiaschi

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of repetitive transcranial magnetic stimulation has recently been employed as a potential treatment of depression. Based on the hypothesis that major depression may result from decreased activity on the left frontal function, high-frequency rTMS has been applied to the left frontal lobe, producing a mild, but significantly clinical improvement in the mood of depressed patients after the period of stimulation. No information exists on the long-term effect of the high-frequency rTMS on the patients affected by major depression. The aim of this study was to access the short- and long-term effect of rTMS on depressed patients. We performed the protocol of high- frequency rTMS performed by George (1995). We administered rTMS each morning for 1 week (5 days) to the left frontal cortex in 16 patients (mean age 48 years) with primary mood disorders (8 bipolar disorders, 6 unipolar disorder). Each morning subjects received 20 2-s trains of rTMS at 20 Hz at 80% of motor threshold in muscles of right thenar eminence (TE). Repetitive TMS was applied to the left frontal hemisphere using a circular coil. Of 16 patients 11 patients were stimulated using the real rTMS, while 5 patients were stimulated using a placebo stimulation. Hamilton D and Beck inventory scales were performed before (Tl) and after (T2) the treatment protocol and after 1 month (T3) of the rTMS. No adverse outcomes were noted in either group. A significant antidepressant effect was noted in 9/11 treated patients on Hamilton and Beck depression rating scale (P

Original languageEnglish
JournalNeurological Sciences
Volume21
Issue number4 SUPPL.
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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