Left prefrontal cortex control of novel occurrences during recollection

A psychopharmacological study using scopolamine and event-related fMRI

M. Bozzali, S. E. MacPherson, R. J. Dolan, T. Shallice

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Recollection and familiarity represent two processes involved in episodic memory retrieval. We investigated how scopolamine (an antagonist of acetylcholine muscarinic receptors) influenced brain activity during memory retrieval, using a paradigm that separated recollection and familiarity. Eighteen healthy volunteers were recruited in a randomized, placebo-controlled, double-blind design using event-related fMRI. Participants were required to perform a verbal recognition memory task within the scanner, either under placebo or scopolamine conditions. Depending on the subcondition, participants were required to make a simple recognition decision (old/new items) or base their decision on more specific information related to prior experience (target/non-target/new items). We show a drug modulation in left prefrontal and perirhinal cortex during recollection. Such an effect was specifically driven by novelty and showed an inverse correlation with accuracy performance. Additionally, we show a direct correlation between drug-related signal change in left prefrontal and perirhinal cortices. We discuss the findings in terms of acetylcholine mediation of the familiarity/novelty signal through perirhinal cortex and the control of the relative signal strength through prefrontal cortex.

Original languageEnglish
Pages (from-to)286-295
Number of pages10
JournalNeuroImage
Volume33
Issue number1
DOIs
Publication statusPublished - Oct 15 2006

Fingerprint

Scopolamine Hydrobromide
Prefrontal Cortex
Magnetic Resonance Imaging
Placebos
Episodic Memory
Muscarinic Receptors
Pharmaceutical Preparations
Acetylcholine
Healthy Volunteers
Recognition (Psychology)
Brain
Perirhinal Cortex

Keywords

  • Episodic memory
  • Familiarity
  • fMRI
  • Recollection
  • Scopolamine

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Left prefrontal cortex control of novel occurrences during recollection : A psychopharmacological study using scopolamine and event-related fMRI. / Bozzali, M.; MacPherson, S. E.; Dolan, R. J.; Shallice, T.

In: NeuroImage, Vol. 33, No. 1, 15.10.2006, p. 286-295.

Research output: Contribution to journalArticle

@article{902a8cf92e924cd0a19f6bc4f33a8668,
title = "Left prefrontal cortex control of novel occurrences during recollection: A psychopharmacological study using scopolamine and event-related fMRI",
abstract = "Recollection and familiarity represent two processes involved in episodic memory retrieval. We investigated how scopolamine (an antagonist of acetylcholine muscarinic receptors) influenced brain activity during memory retrieval, using a paradigm that separated recollection and familiarity. Eighteen healthy volunteers were recruited in a randomized, placebo-controlled, double-blind design using event-related fMRI. Participants were required to perform a verbal recognition memory task within the scanner, either under placebo or scopolamine conditions. Depending on the subcondition, participants were required to make a simple recognition decision (old/new items) or base their decision on more specific information related to prior experience (target/non-target/new items). We show a drug modulation in left prefrontal and perirhinal cortex during recollection. Such an effect was specifically driven by novelty and showed an inverse correlation with accuracy performance. Additionally, we show a direct correlation between drug-related signal change in left prefrontal and perirhinal cortices. We discuss the findings in terms of acetylcholine mediation of the familiarity/novelty signal through perirhinal cortex and the control of the relative signal strength through prefrontal cortex.",
keywords = "Episodic memory, Familiarity, fMRI, Recollection, Scopolamine",
author = "M. Bozzali and MacPherson, {S. E.} and Dolan, {R. J.} and T. Shallice",
year = "2006",
month = "10",
day = "15",
doi = "10.1016/j.neuroimage.2006.06.044",
language = "English",
volume = "33",
pages = "286--295",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Left prefrontal cortex control of novel occurrences during recollection

T2 - A psychopharmacological study using scopolamine and event-related fMRI

AU - Bozzali, M.

AU - MacPherson, S. E.

AU - Dolan, R. J.

AU - Shallice, T.

PY - 2006/10/15

Y1 - 2006/10/15

N2 - Recollection and familiarity represent two processes involved in episodic memory retrieval. We investigated how scopolamine (an antagonist of acetylcholine muscarinic receptors) influenced brain activity during memory retrieval, using a paradigm that separated recollection and familiarity. Eighteen healthy volunteers were recruited in a randomized, placebo-controlled, double-blind design using event-related fMRI. Participants were required to perform a verbal recognition memory task within the scanner, either under placebo or scopolamine conditions. Depending on the subcondition, participants were required to make a simple recognition decision (old/new items) or base their decision on more specific information related to prior experience (target/non-target/new items). We show a drug modulation in left prefrontal and perirhinal cortex during recollection. Such an effect was specifically driven by novelty and showed an inverse correlation with accuracy performance. Additionally, we show a direct correlation between drug-related signal change in left prefrontal and perirhinal cortices. We discuss the findings in terms of acetylcholine mediation of the familiarity/novelty signal through perirhinal cortex and the control of the relative signal strength through prefrontal cortex.

AB - Recollection and familiarity represent two processes involved in episodic memory retrieval. We investigated how scopolamine (an antagonist of acetylcholine muscarinic receptors) influenced brain activity during memory retrieval, using a paradigm that separated recollection and familiarity. Eighteen healthy volunteers were recruited in a randomized, placebo-controlled, double-blind design using event-related fMRI. Participants were required to perform a verbal recognition memory task within the scanner, either under placebo or scopolamine conditions. Depending on the subcondition, participants were required to make a simple recognition decision (old/new items) or base their decision on more specific information related to prior experience (target/non-target/new items). We show a drug modulation in left prefrontal and perirhinal cortex during recollection. Such an effect was specifically driven by novelty and showed an inverse correlation with accuracy performance. Additionally, we show a direct correlation between drug-related signal change in left prefrontal and perirhinal cortices. We discuss the findings in terms of acetylcholine mediation of the familiarity/novelty signal through perirhinal cortex and the control of the relative signal strength through prefrontal cortex.

KW - Episodic memory

KW - Familiarity

KW - fMRI

KW - Recollection

KW - Scopolamine

UR - http://www.scopus.com/inward/record.url?scp=33748712829&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748712829&partnerID=8YFLogxK

U2 - 10.1016/j.neuroimage.2006.06.044

DO - 10.1016/j.neuroimage.2006.06.044

M3 - Article

VL - 33

SP - 286

EP - 295

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

IS - 1

ER -