Left-right asymmetry of the gnathostome skull: Its evolutionary, developmental, and functional aspects

Claudia Compagnucci, Jennifer Fish, Michael J. Depew

Research output: Contribution to journalArticle


Summary: Much of the gnathostome (jawed vertebrate) evolutionary radiation was dependent on the ability to sense and interpret the environment and subsequently act upon this information through utilization of a specialized mode of feeding involving the jaws. While the gnathostome skull, reflective of the vertebrate baüplan, typically is bilaterally symmetric with right (dextral) and left (sinistral) halves essentially representing mirror images along the midline, both adaptive and abnormal asymmetries have appeared. Herein we provide a basic primer on studies of the asymmetric development of the gnathostome skull, touching briefly on asymmetry as a field of study, then describing the nature of cranial development and finally underscoring evolutionary and functional aspects of left-right asymmetric cephalic development. genesis 52:515-527, 2014.

Original languageEnglish
Pages (from-to)515-527
Number of pages13
Issue number6
Publication statusPublished - 2014



  • Adaptive asymmetry
  • Craniofacial
  • Dlx5
  • Fgf8
  • Lambdoidal junction
  • Satb2

ASJC Scopus subject areas

  • Endocrinology
  • Cell Biology
  • Genetics
  • Medicine(all)

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