Abstract
The possibility that denervation Supersensitivity might result from left Stellectomy was investigated because of its potential clinical implications. The study was conducted in 12 conscious dogs by injecting norepinephrine as a bolus dose or as an infusion before and 2 to 4 weeks after left Stellectomy. The variables analyzed were the first derivative of left ventricular pressure (dP/dt max) and the number of premature ventricular complexes. Under control conditions dP/dt max was unaffected by left Stellectomy (3,572 ± 280 versus 3,549 ± 235 mm Hg/s). Bolus injections and infusions produced the same results and showed no difference in the increases in dP/dt max produced by norepinephrine observed before and after left Stellectomy. For example, with the largest dose of norepinephrine, 1.25 μg/kg, the changes from the control value were 4,533 ± 269 and 5,032 ± 668 mm Hg/s, respectively (difference not significant). The number of premature ventricular complexes resulting from the two largest doses of norepinephrine was significantly decreased after left Stellectomy (85 ±12 versus 46 ± 14, p <0.05), and ventricular tachycardia, which occurred in three dogs under control conditions, was never observed after left Stellectomy. This study reveals another aspect of the antiarrhythmic effect of left Stellectomy and demonstrates that it does not produce denervation Supersensitivity.
| Original language | English |
|---|---|
| Pages (from-to) | 1185-1190 |
| Number of pages | 6 |
| Journal | The American Journal of Cardiology |
| Volume | 49 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Apr 1 1982 |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Left stellectomy and denervation supersensitivity in conscious dogs. / Schwartz, Peter J.; Stone, H. Lowell.
In: The American Journal of Cardiology, Vol. 49, No. 5, 01.04.1982, p. 1185-1190.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Left stellectomy and denervation supersensitivity in conscious dogs
AU - Schwartz, Peter J.
AU - Stone, H. Lowell
PY - 1982/4/1
Y1 - 1982/4/1
N2 - The possibility that denervation Supersensitivity might result from left Stellectomy was investigated because of its potential clinical implications. The study was conducted in 12 conscious dogs by injecting norepinephrine as a bolus dose or as an infusion before and 2 to 4 weeks after left Stellectomy. The variables analyzed were the first derivative of left ventricular pressure (dP/dt max) and the number of premature ventricular complexes. Under control conditions dP/dt max was unaffected by left Stellectomy (3,572 ± 280 versus 3,549 ± 235 mm Hg/s). Bolus injections and infusions produced the same results and showed no difference in the increases in dP/dt max produced by norepinephrine observed before and after left Stellectomy. For example, with the largest dose of norepinephrine, 1.25 μg/kg, the changes from the control value were 4,533 ± 269 and 5,032 ± 668 mm Hg/s, respectively (difference not significant). The number of premature ventricular complexes resulting from the two largest doses of norepinephrine was significantly decreased after left Stellectomy (85 ±12 versus 46 ± 14, p <0.05), and ventricular tachycardia, which occurred in three dogs under control conditions, was never observed after left Stellectomy. This study reveals another aspect of the antiarrhythmic effect of left Stellectomy and demonstrates that it does not produce denervation Supersensitivity.
AB - The possibility that denervation Supersensitivity might result from left Stellectomy was investigated because of its potential clinical implications. The study was conducted in 12 conscious dogs by injecting norepinephrine as a bolus dose or as an infusion before and 2 to 4 weeks after left Stellectomy. The variables analyzed were the first derivative of left ventricular pressure (dP/dt max) and the number of premature ventricular complexes. Under control conditions dP/dt max was unaffected by left Stellectomy (3,572 ± 280 versus 3,549 ± 235 mm Hg/s). Bolus injections and infusions produced the same results and showed no difference in the increases in dP/dt max produced by norepinephrine observed before and after left Stellectomy. For example, with the largest dose of norepinephrine, 1.25 μg/kg, the changes from the control value were 4,533 ± 269 and 5,032 ± 668 mm Hg/s, respectively (difference not significant). The number of premature ventricular complexes resulting from the two largest doses of norepinephrine was significantly decreased after left Stellectomy (85 ±12 versus 46 ± 14, p <0.05), and ventricular tachycardia, which occurred in three dogs under control conditions, was never observed after left Stellectomy. This study reveals another aspect of the antiarrhythmic effect of left Stellectomy and demonstrates that it does not produce denervation Supersensitivity.
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UR - http://www.scopus.com/inward/citedby.url?scp=0019943788&partnerID=8YFLogxK
U2 - 10.1016/0002-9149(82)90043-1
DO - 10.1016/0002-9149(82)90043-1
M3 - Article
C2 - 6175200
AN - SCOPUS:0019943788
VL - 49
SP - 1185
EP - 1190
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 5
ER -