Left ventricle remodeling in patients with β-thalassemia major. An emerging differential diagnosis with left ventricle noncompaction disease

Elisabetta Chiodi, Marianna Nardozza, Maria Rita Gamberini, Alessia Pepe, Massimo Lombardi, Giorgio Benea, Donato Mele

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

© 2017 Elsevier Inc. To differentiate left ventricle non-compaction (LVNC) from hypertrabeculated myocardium due to LV remodeling in β-thalassemia major (β-TM) patients, cardiac magnetic resonance (CMR) images of 38 β-TM patients and 10 LVNC patients were compared using 3 diagnostic criteria: ratio of diastolic segmental non-compacted to compacted myocardium (NC/C ratio) >  2.5, percentage of non-compacted LV mass (NC-LVM%) >  20% and >  25% of global LV mass. Specificity of NC/C ratio of >  2.5 was the lowest (58%) and of NC-LVM% of >  25% the highest (93%). A NC-LVM% >  20% showed sensitivity 100% and specificity 87%. Disease differentiation depends on the selected CMR criterion and is better with NC-LVM%.
Original languageEnglish
Pages (from-to)58-64
Number of pages7
JournalClinical Imaging
Volume45
DOIs
Publication statusPublished - Sep 1 2017

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Ventricular Remodeling
beta-Thalassemia
Heart Ventricles
Differential Diagnosis
Myocardium
Magnetic Resonance Spectroscopy
Sensitivity and Specificity

Keywords

  • Cardiomyopathy
  • Heart failure
  • Left ventricle non compaction
  • Magnetic resonance imaging
  • β-thalassemia

Cite this

Left ventricle remodeling in patients with β-thalassemia major. An emerging differential diagnosis with left ventricle noncompaction disease. / Chiodi, Elisabetta; Nardozza, Marianna; Gamberini, Maria Rita; Pepe, Alessia; Lombardi, Massimo; Benea, Giorgio; Mele, Donato.

In: Clinical Imaging, Vol. 45, 01.09.2017, p. 58-64.

Research output: Contribution to journalArticle

Chiodi, Elisabetta ; Nardozza, Marianna ; Gamberini, Maria Rita ; Pepe, Alessia ; Lombardi, Massimo ; Benea, Giorgio ; Mele, Donato. / Left ventricle remodeling in patients with β-thalassemia major. An emerging differential diagnosis with left ventricle noncompaction disease. In: Clinical Imaging. 2017 ; Vol. 45. pp. 58-64.
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AU - Lombardi, Massimo

AU - Benea, Giorgio

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