TY - JOUR
T1 - Left Ventricular Diastolic Filling Pattern at Doppler Echocardiography and Apoptotic Rate in Fatal Acute Myocardial Infarction
AU - Sinagra, Gianfranco
AU - Bussani, Rossana
AU - Abbate, Antonio
AU - Piro, Maddalena
AU - Biondi-Zoccai, Giuseppe G L
AU - Kontos, Michael C.
AU - Sabbadini, Gastone
AU - Barresi, Elena
AU - Crea, Filippo
AU - Biasucci, Luigi M.
AU - Aleksova, Aneta
AU - Pinamonti, Bruno
AU - Silvestri, Furio
AU - Vetrovec, George W.
AU - Baldi, Alfonso
PY - 2007/2/1
Y1 - 2007/2/1
N2 - Heart failure is a complex syndrome characterized by impaired emptying and/or impaired filling of the heart chambers. The use of parameters of diastolic function has provided novel tools for risk stratification and management of patients with heart failure. This study evaluated the potential correlation between apoptosis at time of death and left ventricular (LV) diastolic function after acute myocardial infarction. We selected, at routine postmortem examination, 14 subjects who died 10 to 62 days after an acute myocardial infarction and had an available echocardiographic report from the most recent hospital admission. The apoptotic rate was calculated at the region bordering the infarct, using co-localization of in situ end-labeling for deoxyribonucleic acid fragmentation and immunohistochemistry for caspase-3. Transthoracic echocardiographic studies were retrospectively reevaluated and pulse-wave Doppler spectra of mitral inflow were analyzed. LV diastolic function was assessed by measuring the ratio of E peak velocity to A peak velocity and E-wave deceleration time; a ratio of E peak velocity to A peak velocity ≥2 and deceleration time
AB - Heart failure is a complex syndrome characterized by impaired emptying and/or impaired filling of the heart chambers. The use of parameters of diastolic function has provided novel tools for risk stratification and management of patients with heart failure. This study evaluated the potential correlation between apoptosis at time of death and left ventricular (LV) diastolic function after acute myocardial infarction. We selected, at routine postmortem examination, 14 subjects who died 10 to 62 days after an acute myocardial infarction and had an available echocardiographic report from the most recent hospital admission. The apoptotic rate was calculated at the region bordering the infarct, using co-localization of in situ end-labeling for deoxyribonucleic acid fragmentation and immunohistochemistry for caspase-3. Transthoracic echocardiographic studies were retrospectively reevaluated and pulse-wave Doppler spectra of mitral inflow were analyzed. LV diastolic function was assessed by measuring the ratio of E peak velocity to A peak velocity and E-wave deceleration time; a ratio of E peak velocity to A peak velocity ≥2 and deceleration time
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U2 - 10.1016/j.amjcard.2006.08.025
DO - 10.1016/j.amjcard.2006.08.025
M3 - Article
C2 - 17261387
AN - SCOPUS:33846411470
VL - 99
SP - 307
EP - 309
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 3
ER -