Left Ventricular Diastolic Filling Pattern at Doppler Echocardiography and Apoptotic Rate in Fatal Acute Myocardial Infarction

Gianfranco Sinagra, Rossana Bussani, Antonio Abbate, Maddalena Piro, Giuseppe G L Biondi-Zoccai, Michael C. Kontos, Gastone Sabbadini, Elena Barresi, Filippo Crea, Luigi M. Biasucci, Aneta Aleksova, Bruno Pinamonti, Furio Silvestri, George W. Vetrovec, Alfonso Baldi

Research output: Contribution to journalArticlepeer-review

Abstract

Heart failure is a complex syndrome characterized by impaired emptying and/or impaired filling of the heart chambers. The use of parameters of diastolic function has provided novel tools for risk stratification and management of patients with heart failure. This study evaluated the potential correlation between apoptosis at time of death and left ventricular (LV) diastolic function after acute myocardial infarction. We selected, at routine postmortem examination, 14 subjects who died 10 to 62 days after an acute myocardial infarction and had an available echocardiographic report from the most recent hospital admission. The apoptotic rate was calculated at the region bordering the infarct, using co-localization of in situ end-labeling for deoxyribonucleic acid fragmentation and immunohistochemistry for caspase-3. Transthoracic echocardiographic studies were retrospectively reevaluated and pulse-wave Doppler spectra of mitral inflow were analyzed. LV diastolic function was assessed by measuring the ratio of E peak velocity to A peak velocity and E-wave deceleration time; a ratio of E peak velocity to A peak velocity ≥2 and deceleration time

Original languageEnglish
Pages (from-to)307-309
Number of pages3
JournalThe American Journal of Cardiology
Volume99
Issue number3
DOIs
Publication statusPublished - Feb 1 2007

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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