TY - JOUR
T1 - Left Ventricular Diastolic Function in Healthy Adult Individuals
T2 - Results of the World Alliance Societies of Echocardiography Normal Values Study
AU - WASE Investigators
AU - Miyoshi, Tatsuya
AU - Addetia, Karima
AU - Citro, Rodolfo
AU - Daimon, Masao
AU - Desale, Sameer
AU - Fajardo, Pedro Gutierrez
AU - Kasliwal, Ravi R.
AU - Kirkpatrick, James N.
AU - Monaghan, Mark J.
AU - Muraru, Denisa
AU - Ogunyankin, Kofo O.
AU - Park, Seung Woo
AU - Ronderos, Ricardo E.
AU - Sadeghpour, Anita
AU - Scalia, Gregory M.
AU - Takeuchi, Masaaki
AU - Tsang, Wendy
AU - Tucay, Edwin S.
AU - Tude Rodrigues, Ana Clara
AU - Vivekanandan, Amuthan
AU - Zhang, Yun
AU - Blitz, Alexandra
AU - Lang, Roberto M.
AU - Asch, Federico M.
AU - Prado, Aldo D.
AU - Filipini, Eduardo
AU - Kwon, Agatha
AU - Hoschke-Edwards, Samantha
AU - Regina Afonso, Tania
AU - Thampinathan, Babitha
AU - Sooriyakanthan, Maala
AU - Zhu, Tiangang
AU - Wang, Zhilong
AU - Wang, Yingbin
AU - Zhang, Mei
AU - Zhang, Yu
AU - Yin, Lixue
AU - Li, Shuang
AU - Alagesan, R.
AU - Balasubramanian, S.
AU - Ananth, R. V.A.
AU - Bansal, Manish
AU - Badano, Luigi P.
AU - Palermo, Chiara
AU - Bossone, Eduardo
AU - Di Vece, Davide
AU - Bellino, Michele
AU - Nakao, Tomoko
AU - Kawata, Takayuki
AU - Hirokawa, Megumi
N1 - Funding Information:
This work was supported by the American Society of Echocardiography Foundation, MedStar Health Research Institute, and the University of Chicago, with in-kind support from TOMTEC and Intelemage/Medidata.
Publisher Copyright:
© 2020 American Society of Echocardiography
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/10
Y1 - 2020/10
N2 - Background: The World Alliance Societies of Echocardiography (WASE) study was conducted to describe echocardiographic normal values in adults and to compare races and nationalities using a uniform acquisition and measurement protocol. This report focuses on left ventricular (LV) diastolic function. Methods: WASE is an international, cross-sectional study. Participants were enrolled with equal distribution according to age and gender. Echocardiograms were analyzed in a core laboratory based on the latest American Society of Echocardiography/European Association of Cardiovascular Imaging guidelines. Left ventricular diastolic function was assessed by E, E/A, e' velocities, E/e', left atrial volume index (LAVI), and tricuspid regurgitation velocity. Determination of LV diastolic function was made using the algorithm proposed by the guidelines. Results: A total of 2,008 subjects from 15 countries were enrolled. The majority were of white or Asian race (42.8%, 41.8%, respectively). E and E/e' were higher in female patients, while LAVI was similar in both genders. Consistent increase in E/e' and decrease in E/A, E, and e' were found as age increased. The upper limit of normal for LAVI was higher in WASE compared with the guidelines. The lower limits of normal for e' were smaller in elder groups than those in the guidelines, while the upper limits of normal for E/e' were below the guideline values. These findings suggest that the cutoff value for LAVI should be shifted upward and age-specific cutoff values for e' should be considered. In WASE, <93.6% of patients were classified as normal LV diastolic function using the guidelines' algorithm, and the proportion increased to 97.4% when applying the revised cutoff values for LAVI obtained in our study. Conclusions: Guideline-recommended normal values for e' velocities and LAVI should be reconsidered. The algorithm for the determination of LV diastolic function proposed by the guidelines is useful, but adjustments to LAVI could further improve it.
AB - Background: The World Alliance Societies of Echocardiography (WASE) study was conducted to describe echocardiographic normal values in adults and to compare races and nationalities using a uniform acquisition and measurement protocol. This report focuses on left ventricular (LV) diastolic function. Methods: WASE is an international, cross-sectional study. Participants were enrolled with equal distribution according to age and gender. Echocardiograms were analyzed in a core laboratory based on the latest American Society of Echocardiography/European Association of Cardiovascular Imaging guidelines. Left ventricular diastolic function was assessed by E, E/A, e' velocities, E/e', left atrial volume index (LAVI), and tricuspid regurgitation velocity. Determination of LV diastolic function was made using the algorithm proposed by the guidelines. Results: A total of 2,008 subjects from 15 countries were enrolled. The majority were of white or Asian race (42.8%, 41.8%, respectively). E and E/e' were higher in female patients, while LAVI was similar in both genders. Consistent increase in E/e' and decrease in E/A, E, and e' were found as age increased. The upper limit of normal for LAVI was higher in WASE compared with the guidelines. The lower limits of normal for e' were smaller in elder groups than those in the guidelines, while the upper limits of normal for E/e' were below the guideline values. These findings suggest that the cutoff value for LAVI should be shifted upward and age-specific cutoff values for e' should be considered. In WASE, <93.6% of patients were classified as normal LV diastolic function using the guidelines' algorithm, and the proportion increased to 97.4% when applying the revised cutoff values for LAVI obtained in our study. Conclusions: Guideline-recommended normal values for e' velocities and LAVI should be reconsidered. The algorithm for the determination of LV diastolic function proposed by the guidelines is useful, but adjustments to LAVI could further improve it.
KW - Diastolic function
KW - Echocardiography
KW - International
KW - Normal values
KW - WASE
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U2 - 10.1016/j.echo.2020.06.008
DO - 10.1016/j.echo.2020.06.008
M3 - Article
C2 - 32741597
AN - SCOPUS:85088970413
VL - 33
SP - 1223
EP - 1233
JO - Journal of the American Society of Echocardiography
JF - Journal of the American Society of Echocardiography
SN - 0894-7317
IS - 10
ER -