Left ventricular dyssynchrony assessed by two three-dimensional imaging modalities: Phase analysis of gated myocardial perfusion SPECT and tri-plane tissue Doppler imaging

Nina Ajmone Marsan, Maureen M. Henneman, Ji Chen, Claudia Ypenburg, Petra Dibbets, Stefano Ghio, Gabe B. Bleeker, Marcel P. Stokkel, Ernst E. Van Der Wall, Luigi Tavazzi, Ernest V. Garcia, Jeroen J. Bax

Research output: Contribution to journalArticle

Abstract

Purpose: To compare left ventricular (LV) dyssynchrony assessment by phase analysis from gated myocardial perfusion SPECT (GMPS) with LV dyssynchrony assessment by tri-plane tissue Doppler imaging (TDI). Baseline LV dyssynchrony assessed with standard deviation (SD) of time-to-peak systolic velocity of 12 LV segments (Ts-SD) with TDI has proven to be a powerful predictor of response to CRT. Information on LV dyssynchrony can also be provided by GMPS with phase analysis of regional LV maximal count changes throughout the cardiac cycle. Methods: Forty heart failure patients, referred for evaluation of potential eligibility for CRT, underwent both 3D echocardiography, with tri-plane TDI, and resting GMPS. From tri-plane TDI, Ts-SD was used as a validated parameter of LV dyssynchrony and compared with different indices (histogram bandwidth, phase SD, histogram skewness and kurtosis) derived from phase analysis of GMPS. Results: Histogram bandwidth and phase SD showed good correlation with Ts-SD (r=0.77 and r=0.74, p

Original languageEnglish
Pages (from-to)166-173
Number of pages8
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume35
Issue number1
DOIs
Publication statusPublished - Jan 2008

Keywords

  • Gated SPECT
  • Heart failure
  • LV dyssynchrony
  • Nuclear imaging
  • TDI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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  • Cite this

    Ajmone Marsan, N., Henneman, M. M., Chen, J., Ypenburg, C., Dibbets, P., Ghio, S., Bleeker, G. B., Stokkel, M. P., Van Der Wall, E. E., Tavazzi, L., Garcia, E. V., & Bax, J. J. (2008). Left ventricular dyssynchrony assessed by two three-dimensional imaging modalities: Phase analysis of gated myocardial perfusion SPECT and tri-plane tissue Doppler imaging. European Journal of Nuclear Medicine and Molecular Imaging, 35(1), 166-173. https://doi.org/10.1007/s00259-007-0539-6