Left ventricular endocardial pacing improves resynchronization therapy in canine left bundle-branch hearts

Frits W. Prinzen, Caroline Van Deursen, Irene E. Van Geldorp, Leonard M. Rademakers, Arne Van Hunnik, Marion Kuiper, Catherine Klersy, Angelo Auricchio

Research output: Contribution to journalArticle

Abstract

Background-We investigated the benefits of the more physiological activation achieved by left ventricular (LV) endocardial pacing (ENDO) as compared with conventional epicardial (EPI) LV pacing in cardiac resynchronization therapy. Methods and Results-In 8 anesthetized dogs with experimental left bundle-branch block, pacing leads were positioned in the right atrium, right ventricle, and at 8 paired (EPI and ENDO) LV sites. Systolic LV pump function was assessed as LVdP/dtmax and stroke work and diastolic function as LVdP/dtmin. Electrical activation and dispersion of repolarization were determined from 122 epicardial and endocardial electrodes and from analysis of the surface ECG. Overall, ENDO-biventricular (BiV) pacing more than doubled the degree of electrical resynchronization and increased the benefit on LVdP/dtmax and stroke work by 90% and 50%, respectively, as compared with EPI-BiV pacing. During single-site LV pacing, the range of AV intervals with a >10% increase in LV resynchronization (79±31 versus 32±24 ms, P

Original languageEnglish
Pages (from-to)580-587
Number of pages8
JournalCirculation: Arrhythmia and Electrophysiology
Volume2
Issue number5
DOIs
Publication statusPublished - Oct 2009

Keywords

  • Bundle-branch block
  • Electrophysiology
  • Hemodynamics
  • Pacing

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Left ventricular endocardial pacing improves resynchronization therapy in canine left bundle-branch hearts'. Together they form a unique fingerprint.

  • Cite this

    Prinzen, F. W., Van Deursen, C., Van Geldorp, I. E., Rademakers, L. M., Van Hunnik, A., Kuiper, M., Klersy, C., & Auricchio, A. (2009). Left ventricular endocardial pacing improves resynchronization therapy in canine left bundle-branch hearts. Circulation: Arrhythmia and Electrophysiology, 2(5), 580-587. https://doi.org/10.1161/CIRCEP.108.846022